ArticleInfection and immunity1994
Binding and activation of major histocompatibility complex class II-deficient macrophages by staphylococcal exotoxins.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 24 citations in OpenAlex.
- Persistent Ehrlichia chaffeensis infection occurs in the absence of functional major histocompatibility complex class II genes.Infection and immunity · 2002Article
- Clinical, microbial, and biochemical aspects of the exfoliative toxins causing staphylococcal scalded-skin syndrome.Clinical microbiology reviews · 1999Review
- Macrophage cell lines derived from major histocompatibility complex II-negative mice.In vitro cellular & developmental biology. Animal · 1998Article
- Analysis of the superantigenic activity of mutant and allelic forms of streptococcal pyrogenic exotoxin A.Infection and immunity · 1996Article
- Staphylococcal enterotoxins bind H-2Db molecules on macrophages.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Bacterial pyrogenic exotoxins as superantigens.Clinical microbiology reviews · 1995Review
- Superantigens and pseudosuperantigens of gram-positive cocci.Medical microbiology and immunology · 1995Review
- The potential role of superantigens in inflammatory bowel disease.Clinical and experimental immunology · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Macrophages from C2D transgenic mice deficient in the expression of major histocompatibility complex (MHC) class II proteins were used to identify binding sites for superantigens distinct from the MHC class II molecule. Iodinated staphylococcal enterotoxins A and B (SEA and SEB) and exfoliative toxins A and B (ETA and ETB) bound to C2D macrophages in a concentration-dependent and competitive manner. All four toxins increased F-actin concentration within 30 s of their addition to C2D macrophages, indicating that signal transduction occurred in response to toxin in the absence of class II MHC. Furthermore, ETA, ETB, SEA, and, to a lesser extent, SEB induced C2D macrophages to produce interleukin 6. Several molecular species on C2D macrophages with molecular masses of 140, 97, 61, 52, 43, and 37 kDa bound SEA in immunoprecipitation experiments. These data indicate the presence of novel, functionally active toxin binding sites on murine macrophages distinct from MHC class II molecules.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.