ArticleInfection and immunity1994
Blood transfusion alters the course and outcome of Plasmodium chabaudi AS infection in mice.
Article in Infection and immunity, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- Targeting anemia-induced CD71Infection and immunity · 2025Article
- Whole blood transfusion improves vascular integrity and increases survival in artemether-treated experimental cerebral malaria.Scientific reports · 2021Article
- The contribution of host cell-directed vs. parasite-directed immunity to the disease and dynamics of malaria infections.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Elimination of intravascular thrombi prevents early mortality and reduces gliosis in hyper-inflammatory experimental cerebral malaria.Journal of neuroinflammation · 2018Article
- What Controls the Acute Viral Infection Following Yellow Fever Vaccination?Bulletin of mathematical biology · 2018Article
- Within-host competition and drug resistance in the human malaria parasite Plasmodium falciparum.Proceedings. Biological sciences · 2016Article
- South-East Asian strains ofF1000Research · 2016Article
- The fitness of drug-resistant malaria parasites in a rodent model: multiplicity of infection.Journal of evolutionary biology · 2011Article
- The evolution of drug resistance and the curious orthodoxy of aggressive chemotherapy.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Article
- Competitive release and facilitation of drug-resistant parasites after therapeutic chemotherapy in a rodent malaria model.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Transmission stage investment of malaria parasites in response to in-host competition.Proceedings. Biological sciences · 2007Article
- A critical role for the host mediator macrophage migration inhibitory factor in the pathogenesis of malarial anemia.The Journal of experimental medicine · 2006Article
- Top-down or bottom-up regulation of intra-host blood-stage malaria: do malaria parasites most resemble the dynamics of prey or predator?Proceedings. Biological sciences · 2003Article
- Selection for high and low virulence in the malaria parasite Plasmodium chabaudi.Proceedings. Biological sciences · 1999Article
- Therapy with a combination of low doses of interleukin 12 and chloroquine completely cures blood-stage malaria, prevents severe anemia, and induces immunity to reinfection.Infection and immunity · 1999Article
- A target for intervention in Plasmodium falciparum infections.The American journal of tropical medicine and hygiene · 1998Article
- Mixed-genotype infections of malaria parasites: within-host dynamics and transmission success of competing clones.Proceedings. Biological sciences · 1997Article
Corrections and comments
- Erratum issued
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The importance of severe anemia in the mortality of susceptible A/J mice during blood-stage Plasmodium chabaudi AS infection was assessed. Blood transfusion during and 2 to 3 days after peak parasitemia rescued 90% of susceptible mice from severe anemia and death and allowed these mice to clear the infection and acquire immunity to reinfection. However, blood transfusion prolonged the patency of the infection for up to 5 days after peak parasitemia. Blood transfusions in resistant C57BL/6 mice produced an identical effect, that is, prolongation of the patency of parasitemia. In addition, blood transfusion increased the numbers of gametocytes in both mouse strains. In both strains of mice, the rapid reduction in parasitemia, which occurs during crisis, was associated with the development of moderate levels of anemia. The possible mechanisms for the modulation of parasitemia by blood transfusion and the implications of the present observations for our understanding of the events which occur during crisis are discussed. It is proposed that parasitologic crisis is induced and/or maintained by physiological alterations associated with anemia.
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