ArticleThe EMBO journal1994
Constitutive overexpression of the Drosophila period protein inhibits period mRNA cycling.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers.
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Who cites it
83 citing papers in PubMed, 218 citations in OpenAlex.
- The role of circadian rhythm regulator PERs in oxidative stress, immunity, and cancer development.Cell communication and signaling : CCS · 2025Review
- Functional Analyses of Four Cryptochromes From Aquatic Organisms After Heterologous Expression inJournal of biological rhythms · 2024Article
- Circadian rhythms in the Drosophila eye may regulate adaptation of vision to light intensity.Frontiers in neuroscience · 2024Article
- Biological clock regulation by theFrontiers in cell and developmental biology · 2024Review
- Visual and circadian regulation ofiScience · 2023Article
- Decoupling PER phosphorylation, stability and rhythmic expression from circadian clock function by abolishing PER-CK1 interaction.Nature communications · 2022Article
- A natural timeless polymorphism allowing circadian clock synchronization in "white nights".Nature communications · 2022Article
- Roles of peripheral clocks: lessons from the fly.FEBS letters · 2022Review
- PERIOD Phosphoclusters Control Temperature Compensation of theFrontiers in physiology · 2022Article
- Phosphatase of Regenerating Liver-1 Selectively Times Circadian Behavior in Darkness via Function in PDF Neurons and Dephosphorylation of TIMELESS.Current biology : CB · 2021Article
- Contribution of Social Influences through Superposition of Visual and Olfactory Inputs to Circadian Re-entrainment.iScience · 2020Article
- Review
- Mechanisms of circadian clock interactions with aryl hydrocarbon receptor signalling.The European journal of neuroscience · 2020Article
- Biological Oscillators in Nanonetworks-Opportunities and Challenges.Sensors (Basel, Switzerland) · 2018Review
- Cardinal Epigenetic Role of non-coding Regulatory RNAs in Circadian Rhythm.Molecular neurobiology · 2018Review
- Article
- The discoveries of molecular mechanisms for the circadian rhythm: The 2017 Nobel Prize in Physiology or Medicine.Biomedical journal · 2018Article
- The role of the circadian clock system in physiology.Pflugers Archiv : European journal of physiology · 2018Review
- A 50-Year Personal Journey: Location, Gene Expression, and Circadian Rhythms.Cold Spring Harbor perspectives in biology · 2017Article
- Article
23 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila period gene (per) is a likely component of a circadian pacemaker. per protein (PER) participates in the regulation of its own expression, at least in part at the transcriptional level. There is at present no direct evidence that the effect of PER on its own transcription is intracellular. Results presented in this paper show that (i) the circadian oscillations of both per mRNA and PER protein are quantitatively similar in eye photoreceptor cells and in brain; (ii) constitutive overexpression of PER only in photoreceptors R1-R6 represses endogenous per RNA cycling in these cells but not in other per-expressing cells; (iii) the overexpression construct has no effect on locomotor activity rhythms. These results indicate that the autoregulation of per expression is a direct, intracellular event and suggest that each per-expressing cell contains an autonomous oscillator of which the per feedback loop is a component.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.