ArticleThe EMBO journal1994
A transcriptional silencer controls the developmental expression of the CD4 gene.
Article in The EMBO journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 158 citations in OpenAlex.
- A dual enhancer-attenuator element ensures transient Cdx2 expression during mouse posterior body formation.Developmental cell · 2025Article
- Genome-Wide Silencer Screening Reveals Key Silencer Modulating Reprogramming Efficiency in Mouse Induced Pluripotent Stem Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- A conserved element in the first intron ofFrontiers in immunology · 2024Article
- Identification of non-coding silencer elements and their regulation of gene expression.Nature reviews. Molecular cell biology · 2023Review
- Long-Distance Repression by Human Silencers: Chromatin Interactions and Phase Separation in Silencers.Cells · 2022Review
- An autonomous TCR signal-sensing switch influences CD4/CD8 lineage choice in mice.Communications biology · 2022Article
- Systematic identification of silencers in human cells.Nature genetics · 2020Article
- Silencers in the spotlight.Nature genetics · 2020Article
- Functional Conservation of a Developmental Switch in Mammals since the Jurassic Age.Molecular biology and evolution · 2019Article
- Runx-dependent and silencer-independent repression of a maturation enhancer in the Cd4 gene.Nature communications · 2018Article
- Global dynamics of stage-specific transcription factor binding during thymocyte development.Scientific reports · 2018Article
- Tissue adaptation: Implications for gut immunity and tolerance.The Journal of experimental medicine · 2017Review
- Heritable Gene Regulation in the CD4:CD8 T Cell Lineage Choice.Frontiers in immunology · 2017Review
- What Happens in the Thymus Does Not Stay in the Thymus: How T Cells Recycle the CD4+-CD8+ Lineage Commitment Transcriptional Circuitry To Control Their Function.Journal of immunology (Baltimore, Md. : 1950) · 2016Review
- Using the ENCODE Resource for Functional Annotation of Genetic Variants.Cold Spring Harbor protocols · 2015Review
- Transcriptional control of CD4 and CD8 coreceptor expression during T cell development.Cellular and molecular life sciences : CMLS · 2013Review
- Stage-specific epigenetic gene silencing during thymocyte lineage commitment.F1000prime reports · 2013Article
- ATP-dependent chromatin remodeling in T cells.Biochemistry and cell biology = Biochimie et biologie cellulaire · 2012Review
- The epigenetic landscape of lineage choice: lessons from the heritability of CD4 and CD8 expression.Current topics in microbiology and immunology · 2012Review
- Expanding roles for ThPOK in thymic development.Immunological reviews · 2010Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The appropriate expression of the CD4 glycoprotein is required for T-cell function and development. Here we define the transcriptional control elements in the CD4 locus that convey CD(4+)-specific expression of a marker gene in transgenic mice. Using nuclear run-on experiments, we have determined that the major mechanism for CD4 expression control during development is transcriptional. We have identified a developmental stage- and tissue-specific negative regulatory element in the first intron of the murine CD4 gene that has the characteristics of a transcriptional silencer. The CD4 silencer functions to inhibit marker gene expression at two different stages of T-cell development, as well as in non-T hematopoietic cells, and thus is the critical controlling element responsible for T-cell-specific, as well as developmental- and subclass-specific, expression.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.