ArticleAnnals of biomedical engineering
Strain measurements in cultured vascular smooth muscle cells subjected to mechanical deformation.
Article in Annals of biomedical engineering. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- A Review: Non-Contact and Full-Field Strain Mapping Methods for Experimental Mechanics and Structural Health Monitoring.Sensors (Basel, Switzerland) · 2024Review
- A Microfluidic System with Surface Patterning for Investigating Cavitation Bubble(s)-Cell Interaction and the Resultant Bioeffects at the Single-cell Level.Journal of visualized experiments : JoVE · 2017Article
- Cell membrane deformation and bioeffects produced by tandem bubble-induced jetting flow.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Finite element analysis of the pressure-induced deformation of Schlemm's canal endothelial cells.Biomechanics and modeling in mechanobiology · 2015Article
- A comparative study of mechanical strain, icariin and combination stimulations on improving osteoinductive potential via NF-kappaB activation in osteoblast-like cells.Biomedical engineering online · 2015Article
- Mechanical stretch upregulates proteins involved in Ca2+ sensitization in urinary bladder smooth muscle hypertrophy.American journal of physiology. Cell physiology · 2014Article
- Biomechanics of cardiac electromechanical coupling and mechanoelectric feedback.Journal of biomechanical engineering · 2014Review
- Spiral-wave dynamics in ionically realistic mathematical models for human ventricular tissue: the effects of periodic deformation.Frontiers in physiology · 2014Article
- Mechanical loading promotes mast cell degranulation via RGD-integrin dependent pathways.Journal of biomechanics · 2013Article
- Mechanical strain controls endothelial patterning during angiogenic sprouting.Cellular and molecular bioengineering · 2012Article
- Mitochondrial injury after mechanical stretch of cortical neurons in vitro: biomarkers of apoptosis and selective peroxidation of anionic phospholipids.Journal of neurotrauma · 2012Article
- A stretching device for high-resolution live-cell imaging.Annals of biomedical engineering · 2010Article
- Mechanical strain induces involution-associated events in mammary epithelial cells.BMC cell biology · 2009Article
- Experimental techniques for study of chromatin mechanics in intact nuclei and living cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2008Review
- Review
- Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling.Journal of biomechanics · 2007Article
- Measuring arterial strain induced by endovascular stents.Medical & biological engineering & computing · 1999Article
- Identification of stretch-responsive genes in pulmonary artery smooth muscle cells by a two arbitrary primer-based mRNA differential display approach.Molecular and cellular biochemistry · 1999Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Early work in the field of biomechanics employed rigorous application of the principles of mechanics to the study of the macroscopic structural response of tissues to applied loads. Interest in the functional response of tissues to mechanical stimulation has lead researchers to study the biochemical responses of cells to mechanical loading. Characterization of the experimental system (i.e., specimen geometry and boundary conditions) is no less important on the microscopic scale of the cell than it is for macroscopic tissue testing. We outline a method for appropriate characterization of cell deformation in a cell culture model; describe a system for applying a uniform, isotropic strain field to cells in culture; and demonstrate a dependence of cell deformation on morphology and distribution of adhesion sites. Cultured vascular smooth-muscle cells were mechanically deformed by applying an isotropic strain to the compliant substrate to which they were adhered. The state of strain in the cells was determined by measurement of the displacements of fluorescent microspheres attached to the cell surface. The magnitude and orientation of principal strains were found to vary spatially and temporally and to depend on cell morphology. These results show that cell strain can be highly variable and emphasize the need to characterize both the loading conditions and the actual cellular deformation in this type of experimental model.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.