ArticleProceedings of the National Academy of Sciences of the United States of America1994
Electrophysiological analysis of Na+/Pi cotransport mediated by a transporter cloned from rat kidney and expressed in Xenopus oocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 77 citations in OpenAlex.
- The Intricacies of Renal Phosphate Reabsorption-An Overview.International journal of molecular sciences · 2024Review
- (Pro)renin Receptor Regulates Phosphate Homeostasis in RatsFrontiers in physiology · 2022Article
- Mechanisms of phosphate transport.Nature reviews. Nephrology · 2019Review
- Phosphate transport: from microperfusion to molecular cloning.Pflugers Archiv : European journal of physiology · 2019Article
- The molecular mechanism of SLC34 proteins: insights from two decades of transport assays and structure-function studies.Pflugers Archiv : European journal of physiology · 2019Review
- Extracellular phosphates enhance activities of voltage-gated proton channels and production of reactive oxygen species in murine osteoclast-like cells.Pflugers Archiv : European journal of physiology · 2017Article
- Electrogenic kinetics of a mammalian intestinal type IIb Na(+)/P(i) cotransporter.The Journal of membrane biology · 2006Article
- Essential cysteine residues of the type IIa Na+/Pi cotransporter.Pflugers Archiv : European journal of physiology · 2003Article
- Transport function of the renal type IIa Na+/P(i) cotransporter is codetermined by residues in two opposing linker regions.The Journal of general physiology · 2002Article
- The nptA gene of Vibrio cholerae encodes a functional sodium-dependent phosphate cotransporter homologous to the type II cotransporters of eukaryotes.Journal of bacteriology · 2002Article
- Cysteine mutagenesis reveals novel structure-function features within the predicted third extracellular loop of the type IIa Na(+)/P(i) cotransporter.The Journal of general physiology · 2001Article
- Amino acids involved in sodium interaction of murine type II Na(+)-P(i) cotransporters expressed in Xenopus oocytes.The Journal of physiology · 2001Article
- Proton-sensitive transitions of renal type II Na(+)-coupled phosphate cotransporter kinetics.Biophysical journal · 2000Article
- Properties of the mutant Ser-460-Cys implicate this site in a functionally important region of the type IIa Na(+)/P(i) cotransporter protein.The Journal of general physiology · 1999Article
- Functional characterization of a Na+-phosphate cotransporter (NaPi-II) from zebrafish and identification of related transcripts.The Journal of physiology · 1999Article
- Protein kinase C activators induce membrane retrieval of type II Na+-phosphate cotransporters expressed in Xenopus oocytes.The Journal of physiology · 1999Article
- The voltage dependence of a cloned mammalian renal type II Na+/Pi cotransporter (NaPi-2).The Journal of general physiology · 1998Article
- The Na+-phosphate cotransport system (NaPi-II) with a cleaved protein backbone: implications on function and membrane insertion.The Journal of physiology · 1998Article
- The renal type II Na+/phosphate cotransporter.Journal of bioenergetics and biomembranes · 1998Review
- Expression of a renal type I sodium/phosphate transporter (NaPi-1) induces a conductance in Xenopus oocytes permeable for organic and inorganic anions.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
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Authors and funding
8 authors at 1 institution in 1 country.
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Abstract
Phosphate (Pi) reabsorption in renal proximal tubules involves Na+/Pi cotransport across the brush border membrane; its transport rate is influenced by the Na(+)-coupled transport of other solutes as well as by pH. In the present study, we have expressed a cloned rat renal brush border membrane Na+/Pi cotransporter (NaPi-2) in Xenopus laevis oocytes and have analyzed its electrophysiologic properties in voltage- and current-clamp studies. Addition of Pi to Na(+)-containing superfusates resulted in a depolarization of the membrane potential and, in voltage-clamped oocytes, in an inward current (IP). An analysis of the Na+ and/or Pi concentration dependence of IP suggested a Na+/Pi stoichiometry of 3:1. IP was increased by increasing the pH of the superfusate; this phenomenon seems to be mainly related to a lowering of the affinity for Na+ interaction by increasing H+ concentration. The present data suggest that known properties of Pi handling at the tubular/membrane level are "directly" related to specific characteristics of the transport molecule (NaPi-2) involved.
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