ArticleProceedings of the National Academy of Sciences of the United States of America1994
A third synaptotagmin gene, Syt3, in the mouse.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 75 citations in OpenAlex.
- Restricting Synaptotagmin-3 Internalization Mitigates Cerebral Ischemia/Reperfusion Injury by Curtailed Neuronal Apoptosis and Microglial Re-Programming.CNS neuroscience & therapeutics · 2026Article
- Article
- Biallelic loss of function variants in SYT2 cause a treatable congenital onset presynaptic myasthenic syndrome.American journal of medical genetics. Part A · 2020Article
- Synaptotagmin-4 promotes dendrite extension and melanogenesis in alpaca melanocytes by regulating CaCell biochemistry and function · 2020Article
- Rare copy number variants are an important cause of epileptic encephalopathies.Annals of neurology · 2011Article
- Synaptotagmin IV acts as a multi-functional regulator of Ca2+-dependent exocytosis.Neurochemical research · 2011Review
- Rat and Drosophila synaptotagmin 4 have opposite effects during SNARE-catalyzed membrane fusion.The Journal of biological chemistry · 2010Article
- Synaptotagmin IV is necessary for the maturation of secretory granules in PC12 cells.The Journal of cell biology · 2006Article
- Synaptotagmin gene content of the sequenced genomes.BMC genomics · 2004Article
- Neuronal expression of synaptotagmin-related gene 1 is regulated by thyroid hormone during cerebellar development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Deficits in memory and motor performance in synaptotagmin IV mutant mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The first C2 domain of synaptotagmin is required for exocytosis of insulin from pancreatic beta-cells: action of synaptotagmin at low micromolar calcium.The EMBO journal · 1997Article
- Regulation by bivalent cations of phospholipid binding to the C2A domain of synaptotagmin III.The Biochemical journal · 1997Article
- A novel seizure-induced synaptotagmin gene identified by differential display.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Thyroid hormone-responsive genes in developing cerebellum include a novel synaptotagmin and a hairless homolog.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1996Article
- Identification of a nonneuronal isoform of synaptotagmin.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Synaptotagmin IV is an immediate early gene induced by depolarization in PC12 cells and in brain.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Two components of transmitter release at a central synapse.Proceedings of the National Academy of Sciences of the United States of America · 1994Article
- Synaptotagmin IV: biochemistry, genetics, behavior, and possible links to human psychiatric disease.Molecular neurobiologyReview
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca2+ sensors in the process of vesicular trafficking and exocytosis. Results from antibody microinjection and gene-disruption experiments have led to a controversy over whether synaptotagmins are essential for neurotransmission. However, the studies casting doubt on the role of synaptotagmins have assumed that no further isoforms of these molecules exist. Here we report the isolation of a third member of the synaptotagmin family (Syt3) from mouse brain. Although retaining the characteristic five-domain structure of the other synaptotagmins, SYT3 is considerably more divergent at the level of amino acid sequence. In the most highly conserved C2 domain, the mammalian synaptotagmins, SYT1 and SYT2, share 88% sequence identity, whereas SYT3 has only approximately 45% identity to either. Overall, SYT3 has the greatest sequence identity with rat SYT2 and marine ray p65A (both 37%), although homology to all of the known synaptotagmins is > 30%. However, SYT3 is most like p65C when comparing domain structure. Syt3 is expressed in many regions of the nervous system but is undetectable in extraneural tissues. The three murine synaptotagmins have differential expression patterns in the brain. Furthermore, in PC12 cells, Syt3 is coexpressed with Syt1 and is more abundant than the latter. This result suggests that individual neurons may have specific combinations of synaptotagmins that could provide for diversity in vesicular release.
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