ArticleProceedings of the National Academy of Sciences of the United States of America1994
Quantitation of human immunodeficiency virus type 1 during pregnancy: relationship of viral titer to mother-to-child transmission and stability of viral load.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 105 citations in OpenAlex.
- Maternal plasma human immunodeficiency virus type 1 RNA level: a determinant and projected threshold for mother-to-child transmission.Proceedings of the National Academy of Sciences of the United States of America · 1995Trial
- Trial
- Antiretroviral treatment, viral load of mothers & perinatal HIV transmission in Mumbai, India.The Indian journal of medical research · 2013Article
- Modeling interventions to assess HIV epidemic impact in Africa.Journal of acquired immune deficiency syndromes (1999) · 2011Article
- Patient and regimen characteristics associated with self-reported nonadherence to antiretroviral therapy.PloS one · 2007Article
- Early pathogenesis of transmucosal feline immunodeficiency virus infection.Journal of virology · 2002Article
- Hepatitis C virus infection in children coinfected with HIV: epidemiology and management.Paediatric drugs · 2002Review
- Perinatal Transmission of HIV: Recognition and Treatment Interventions.Current infectious disease reports · 2001Article
- Up-regulation of CCR5 expression in the placenta is associated with human immunodeficiency virus-1 vertical transmission.The American journal of pathology · 2000Article
- Frequent detection of escape from cytotoxic T-lymphocyte recognition in perinatal human immunodeficiency virus (HIV) type 1 transmission: the ariel project for the prevention of transmission of HIV from mother to infant.Journal of virology · 1999Article
- The maternal and child health sites' practices regarding HIV education, counseling, and testing of women of reproductive age in Chicago: barriers to universal implementation.Maternal and child health journal · 1998Article
- Materno-fetal transmission of human immune deficiency virus.Infectious diseases in obstetrics and gynecology · 1997Article
- Evaluation of a quality assurance program for quantitation of human immunodeficiency virus type 1 RNA in plasma by the AIDS Clinical Trials Group virology laboratories.Journal of clinical microbiology · 1996Article
- Twin studies demonstrate a host cell genetic effect on productive human immunodeficiency virus infection of human monocytes and macrophages in vitro.Journal of virology · 1996Article
- Characterization of human immunodeficiency virus type 1 p17 matrix protein motifs associated with mother-to-child transmission.Journal of virology · 1996Article
- Frequent perinatal transmission of feline immunodeficiency virus by chronically infected cats.Journal of virology · 1996Article
- Historical and analytical overview of policy issues affecting women living with AIDS: a blueprint for learning from our past.Bulletin of the New York Academy of Medicine · 1995Review
- Guarding against the most dangerous emerging pathogens.Emerging infectious diseasesReview
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
To develop strategies to prevent mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1), it is important to define the factors determining it. We examined the relationship between maternal HIV-1 titer and the occurrence of mother-to-child transmission. In addition, we quantitated HIV-1 longitudinally in mothers during pregnancy, at delivery, and up to 1 year postpartum. To examine transmission, we prospectively studied 19 mother-child pairs; in 5 pairs, HIV-1 transmission occurred. We used endpoint dilution culture of peripheral blood mononuclear cells to determine maternal viral titer and found that although 4 of 6 (67%) women with viral titers of > or = 125 HIV-1 infectious units per 10(6) cells transmitted HIV-1 to their infants, only 1 of 13 (7.6%) women with lower viral titers transmitted (P = 0.01). Twelve of the 19 mothers had HIV-1 loads determined serially 3-8 times over periods ranging from 18 to 65 weeks. Viral titers varied greatly between the 12 women, but the viral load in each woman remained stable over time. In this cohort, HIV-1 viral load remained stable during pregnancy and the greater the maternal viral burden, the more likely that transmission occurred. These two related findings suggest that determination of HIV-1 titers early in pregnancy may predict which women are at high risk of transmitting to their infants and may be used to counsel HIV-1-infected women of childbearing age. These data identify maternal viral titer as a major determinant of mother-to-child HIV-1 transmission and thereby provide the scientific rationale for therapeutic strategies designed to interrupt transmission by lowering viral load.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.