ArticlePharmaceutical research1994
The effect of temperature and pH on the solubility of quinolone compounds: estimation of heat of fusion.
Article in Pharmaceutical research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
17 citing papers in PubMed.
- Dual Release of Antibiotics with Additive Effect from Cleavable Hydrogels Based on Amino/Thiol-Yne Click Chemistry.Biomacromolecules · 2026Article
- Norfloxacin-NSAID Pharmaceutical Salts: Structure-Property Relationships for Enhanced Solubility and Stability.Crystal growth & design · 2026Article
- Correlation Between Dissolution Profiles of Salt-Form Drugs in Biorelevant Bicarbonate Buffer and Oral Drug Absorption: Importance of Dose/ Fluid Volume Ratio.Pharmaceutical research · 2025Article
- Alkalising agents in urinary tract infections: theoretical contraindications, interactions and synergy.Therapeutic advances in drug safety · 2022Article
- Non-intuitive Behavior of Polymer-Ciprofloxacin Nanoconjugate Suspensions: a Tool for Flexible Oral Drug Delivery.AAPS PharmSciTech · 2021Article
- Antimicrobial Activities of Highly Bioavailable Organic Salts and Ionic Liquids from Fluoroquinolones.Pharmaceutics · 2020Article
- Control of the Lung Residence Time of Highly Permeable Molecules after Nebulization: Example of the Fluoroquinolones.Pharmaceutics · 2020Review
- Norfloxacin-Loaded Electrospun Scaffolds: Montmorillonite Nanocomposite vs. Free Drug.Pharmaceutics · 2020Article
- Electrochemical degradation of ciprofloxacin with a Sb-doped SnORSC advances · 2019Article
- Use of Modeling and Simulation Tools for Understanding the Impact of Formulation on the Absorption of a Low Solubility Compound: Ciprofloxacin.The AAPS journal · 2016Article
- Adsorptive Removal and Adsorption Kinetics of Fluoroquinolone by Nano-Hydroxyapatite.PloS one · 2015Article
- Pharmacokinetics and pharmacodynamics of aerosolized antibacterial agents in chronically infected cystic fibrosis patients.Clinical microbiology reviews · 2014Review
- Pharmacological characterization of 7-(4-(Piperazin-1-yl)) ciprofloxacin derivatives: antibacterial activity, cellular accumulation, susceptibility to efflux transporters, and intracellular activity.Pharmaceutical research · 2014Article
- Ecotoxicological effects of ciprofloxacin on freshwater species: data integration and derivation of toxicity thresholds for risk assessment.Ecotoxicology (London, England) · 2012Article
- Inhalable antibiotic delivery using a dry powder co-delivering recombinant deoxyribonuclease and ciprofloxacin for treatment of cystic fibrosis.Pharmaceutical research · 2010Article
- Ultrasonically controlled release of ciprofloxacin from self-assembled coatings on poly(2-hydroxyethyl methacrylate) hydrogels for Pseudomonas aeruginosa biofilm prevention.Antimicrobial agents and chemotherapy · 2005Article
- Solution properties of two fluoroquinolone antibacterials.Pharmaceutical research · 1995Article
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3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although many reports involving fluoroquinolone agents have been published in the past decades, only a few address preformulation studies. In this paper, we describe the effect of temperature and pH on the aqueous solubility of two typically used quinolones, ciprofloxacin and norfloxacin. We measured the aqueous solubilities over the pH range of 5.5 to 9.5 at temperature of 6, 25, 30, and 40 degrees C. The intrinsic solubilities and the thermodynamic dissociation constants were determined from solubility data and the temperature dependence of the intrinsic solubility was evaluated using van't Hoff and Hildebrand plots. The heat of fusion was determined from these two plots. When the heat of fusion was compared to that measured from differential scanning calorimetry (DSC) studies, we found that the Hildebrand method overestimated, and the van't Hoff equation underestimated, the heat of fusion. From the absolute values of the relative errors, the Hildebrand plot produced the better results. DSC results show that the heat of fusion is 15.41 kcal/mol for ciprofloxacin and 7.88 kcal/mol for norfloxacin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.