ArticlePflugers Archiv : European journal of physiology1994
Some properties of the UL-FS 49 block of the hyperpolarization-activated current (i(f)) in sino-atrial node myocytes.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 80 citations in OpenAlex.
- Structure mirroring function: What's the 'matter' with the funny current?The Journal of physiology · 2026Review
- Structural determinants of ivabradine block of the open pore of HCN4.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Review: HCN Channels in the Heart.Current cardiology reviews · 2022Review
- Cardiac and neuronal HCN channelopathies.Pflugers Archiv : European journal of physiology · 2020Review
- Characterization of drug binding within the HCN1 channel pore.Scientific reports · 2019Article
- HCN2 channels: a permanent open state and conductance changes.The Journal of membrane biology · 2015Article
- HCN channels and heart rate.Molecules (Basel, Switzerland) · 2012Review
- Review
- Properties of ivabradine-induced block of HCN1 and HCN4 pacemaker channels.The Journal of physiology · 2006Article
- The pharmacology of cyclic nucleotide-gated channels: emerging from the darkness.Current pharmaceutical design · 2006Review
- Review
- Current-dependent block of rabbit sino-atrial node I(f) channels by ivabradine.The Journal of general physiology · 2002Article
- Blocker state dependence and trapping in hyperpolarization-activated cation channels: evidence for an intracellular activation gate.The Journal of general physiology · 2001Article
- Properties and functional roles of hyperpolarization-gated currents in guinea-pig retinal rods.The Journal of physiology · 1999Article
- I(f) current mediates beta-adrenergic enhancement of heart rate but not contractility in vivo.Basic research in cardiologyArticle
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Authors and funding
1 author at 1 institution in 1 country.
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Abstract
Block of the hyperpolarization-activated "pacemaker" current (i(f)) by the bradycardic agent UL-FS 49 was studied in isolated sino-atrial (SA) node myocytes. Using repetitive activation/deactivation protocols, micromolar concentrations of UL-FS 49 blocked i(f) in a dose-dependent fashion. Block development was slow, with time constants decreasing with drug concentration and ranging from 25.8 s at 10 microM to 75.5 s at 1 microM UL-FS 49. Block did not develop in cells held at -35 mV, at which voltage i(f) channels are closed, indicating that channels must open before blocking occurs. Apparently in contrast with the requirement of negative voltages for block development, block was relieved by hyperpolarization with a time course slower than current kinetics. Due to the hyperpolarization-induced block relief, current/voltage (I/V) relations in the presence of UL-FS 49 displayed inward-going rectification. Experimental data fitted the hypothesis that UL-FS 49 behaves as an "open channel" blocker of "single-ion" i(f) channels. Block occurs within the pore, at a distance of about 39% of the membrane thickness from its internal side.
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