ArticlePflugers Archiv : European journal of physiology1994
The volume-activated chloride current in human endothelial cells depends on intracellular ATP.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 49 citations in OpenAlex.
- Physiological oxygen levels reset KRedox biology · 2026Article
- Physiology of the volume-sensitive/regulatory anion channel VSOR/VRAC. Part 1: from its discovery and phenotype characterization to the molecular entity identification.The journal of physiological sciences : JPS · 2024Review
- Conditional deletion of LRRC8A in the brain reduces stroke damage independently of swelling-activated glutamate release.iScience · 2023Article
- On the molecular nature of large-pore channels.Journal of molecular biology · 2021Review
- ABC transporters control ATP release through cholesterol-dependent volume-regulated anion channel activity.The Journal of biological chemistry · 2020Article
- Metabolic constraints of swelling-activated glutamate release in astrocytes and their implication for ischemic tissue damage.Journal of neurochemistry · 2019Article
- The Volume-Regulated Anion Channel in Glioblastoma.Cancers · 2019Review
- ATP Release Channels.International journal of molecular sciences · 2018Review
- Molecular Biology and Physiology of Volume-Regulated Anion Channel (VRAC).Current topics in membranes · 2018Review
- Cell Volume Control in Healthy Brain and Neuropathologies.Current topics in membranes · 2018Review
- ATP release during cell swelling activates a CaScientific reports · 2017Article
- Volume-activated chloride channels in mice Leydig cells.Pflugers Archiv : European journal of physiology · 2008Article
- ATP release via anion channels.Purinergic signalling · 2005Article
- Dual roles of plasmalemmal chloride channels in induction of cell death.Pflugers Archiv : European journal of physiology · 2004Review
- Inhibition of release of taurine and excitatory amino acids in ischemia and neuroprotection.Neurochemical research · 2004Review
- Functional characterization of recombinant human ClC-4 chloride channels in cultured mammalian cells.The Journal of physiology · 2002Article
- ATP dependence of the ICl,swell channel varies with rate of cell swelling. Evidence for two modes of channel activation.The Journal of general physiology · 1999Article
- Synergetic activation of outwardly rectifying Cl- currents by hypotonic stress and external Ca2+ in murine osteoclasts.The Journal of physiology · 1999Article
- Mitogen-activated protein and tyrosine kinases in the activation of astrocyte volume-activated chloride current.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Regulation of a swelling-activated chloride current in bovine endothelium by protein tyrosine phosphorylation and G proteins.The Journal of physiology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the effect of intracellular ATP on volume-activated CI(-)-currents in endothelial cells from human umbilical veins by means of the whole-cell patch-clamp technique. The run-down of this current in ruptured patches during repetitive applications of hypotonic solutions (HTS) could be significantly reduced if the cells were internally perfused with a pipette solution that contained 4 mmol/l ATP. This run-down was much less pronounced if currents were recorded using nystatin-perforated patches. The amplitude of the current was drastically reduced and its activation became slower if the cells were superfused with a glucose-free medium with 1 mmol/l KCN. Adding 4 mmol/l ATP gamma S, a poorly hydrolyzable ATP-analogue, to the patch pipette prevented run-down of the current during repetitive activations by HTS, even if the cells were superfused with glucose-free solution with 1 mmol/l KCN. It is concluded that activation of the mechanosensitive Cl- conductance in human endothelial cells requires the presence of intracellular ATP, but not its hydrolysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.