ArticlePflugers Archiv : European journal of physiology1994
An electrophysiological study of angiotensin II regulation of Na-HCO3 cotransport and K conductance in renal proximal tubules. II. Effect of micromolar concentrations.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- The role of renal proximal tubule transport in the regulation of blood pressure.Kidney research and clinical practice · 2017Review
- Effects of Nitric Oxide on Renal Proximal Tubular NaBioMed research international · 2017Review
- Regulatory roles of nitric oxide and angiotensin II on renal tubular transport.World journal of nephrology · 2014Review
- Molecular mechanisms and regulation of urinary acidification.Comprehensive Physiology · 2014Review
- NBCe1 as a model carrier for understanding the structure-function properties of Na⁺ -coupled SLC4 transporters in health and disease.Pflugers Archiv : European journal of physiology · 2014Review
- Angiotensin II dose-dependently stimulates human renal proximal tubule transport by the nitric oxide/guanosine 3',5'-cyclic monophosphate pathway.Journal of the American Society of Nephrology : JASN · 2014Article
- Roles of renal proximal tubule transport in acid/base balance and blood pressure regulation.BioMed research international · 2014Review
- Dose-dependent effects of angiotensin-(1-7) on the NHE3 exchanger and [Ca(2+)](i) in in vivo proximal tubules.American journal of physiology. Renal physiology · 2013Article
- Roles of ERK and cPLA2 in the angiotensin II-mediated biphasic regulation of Na+-HCO3(-) transport.Journal of the American Society of Nephrology : JASN · 2008Article
- Effects of pH on kinetic parameters of the Na-HCO3 cotransporter in renal proximal tubule.Biophysical journal · 1999Article
- Voltage and cosubstrate dependence of the Na-HCO3 cotransporter kinetics in renal proximal tubule cells.Biophysical journal · 1998Article
- An electrophysiological study of angiotensin II regulation of Na-HCO3 cotransport and K conductance in renal proximal tubules. I. Effect of picomolar concentrations.Pflugers Archiv : European journal of physiology · 1994Article
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2 authors.
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Abstract
In the first part of our study, we described the effect of picomolar concentrations of angiotensin II (AII) on cell membrane potential (Vb) and cell pH (pHi) of isolated perfused rabbit renal proximal tubules. In the present publication we summarize respective observations with micromolar concentrations of AII. With a few exceptions nearly all experiments showed mirror-image-like results. In the majority of the experiments 10(-6) mol/l AII, when applied from the bath (but not when applied from the lumen), slightly hyperpolarized the cells by -3.4 +/- 0.3 mV (mean +/- SEM, n = 20) and alkalinized them by up to 0.06 pH units, while the lower AII concentrations, which were applied in the previous study, depolarized and acidified. The present observations suggest that micromolar concentrations of AII inhibit basolateral Na-HCO3 cotransport. This conclusion was confirmed by a decreasing Vb response to step changes of basolateral HCO3 concentration. In addition, there was a tendency of the Vb response to K concentration steps to decrease, but measurements of the voltage divider ratio did not point to a significant inhibition of a basolateral K conductance. In spite of the almost perfect reciprocity of the results with 10(-6) and 10(-11) mol/l AII, some specific observations suggest that micromolar concentrations of AII do not simply cause mirror-image-like effects, but influence still further transport systems compared to picomolar concentrations.
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