ArticlePflugers Archiv : European journal of physiology1994
The distribution of intracellular calcium concentration in isolated single fibres of mouse skeletal muscle during fatiguing stimulation.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- Posttetanic potentiation improves neuromuscular efficiency of mouse muscle in vitro.Physiological reports · 2022Article
- Mechanical isolation, and measurement of force and myoplasmic free [CaNature protocols · 2017Article
- Length-dependent Ca2+ activation in skeletal muscle fibers from mammalians.American journal of physiology. Cell physiology · 2016Article
- 'SIT' down and relax: the interpolated twitch technique is still a valid measure of central fatigue during sustained contraction tasks.The Journal of physiology · 2013Article
- Twitch interpolation: superimposed twitches decline progressively during a tetanic contraction of human adductor pollicis.The Journal of physiology · 2013Article
- Effects of membrane depolarization and changes in extracellular [K(+)] on the Ca (2+) transients of fast skeletal muscle fibers. Implications for muscle fatigue.Journal of muscle research and cell motility · 2010Article
- Functional muscle regeneration with combined delivery of angiogenesis and myogenesis factors.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Do multiple ionic interactions contribute to skeletal muscle fatigue?The Journal of physiology · 2008Review
- Limited oxygen diffusion accelerates fatigue development in mouse skeletal muscle.The Journal of physiology · 2006Article
- Inhibition of creatine kinase reduces the rate of fatigue-induced decrease in tetanic [Ca(2+)](i) in mouse skeletal muscle.The Journal of physiology · 2001Article
- Mathematical modeling and fluorescence imaging to study the Ca2+ turnover in skinned muscle fibers.Biophysical journal · 1998Article
- Distribution of sarcomere length and intracellular calcium in mouse skeletal muscle following stretch-induced injury.The Journal of physiology · 1997Article
- Distribution of intracellular calcium in isolated mouse skeletal muscle fibres.Pflugers Archiv : European journal of physiology · 1995Article
- The distribution of intracellular calcium concentration in isolated single fibres of mouse skeletal muscle during fatiguing stimulation.Pflugers Archiv : European journal of physiology · 1994Article
- Examined the activation of central myofibrils during muscle fatigue caused by repeated short tetani.Journal of muscle research and cell motility · 1993Article
Corrections and comments
- Commented on by
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fluorescence microscopy has been used to examine the distribution of intracellular calcium concentration ([Ca2+]i) in isolated single fibres from the mouse flexor brevis muscle during fatiguing stimulation. Under control conditions there was a virtually uniform distribution of [Ca2+]i in fura-2 loaded fibres either at rest or during short (0.35 s, 100 Hz) tetani. Fatigue produced by repeated short tetani was accompanied by an early rise, followed by a marked fall, in tetanic [Ca2+]i. Throughout the period of fatiguing stimulation the distribution of [Ca2+]i remained uniform with no detectable gradients observed. In contrast, when fatigue was produced by continuous 100 Hz stimulation, a small gradient of [Ca2+]i developed across the fibre with the [Ca2+]i in the centre of the fibre lower than that at the edge of the fibre. This gradient was apparent after 1.7 s, persisted for at least 11 s and was superimposed on a rise followed by a fall in spatially averaged [Ca2+]i. Reduction of the extracellular Na+ to 50% caused reduced force production and a reduced [Ca2+]i in the centre of the fibre. To assess the contribution of reduced response of the myofibrillar proteins to [Ca2+]i during continuous tetani, the relation between [Ca2+]i and force throughout the long tetanus was compared with that obtained in short, unfatigued tetani. These results show that in long tetani, reduced tetanic [Ca2+]i and reduced responsiveness of the myofibrillar proteins to [Ca2+]i each make important contributions to the decline of force, whereas the gradients of [Ca2+]i make only a small contribution.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.