ArticleJournal of virology1994
Cytokine induction during T-cell-mediated clearance of mouse hepatitis virus from neurons in vivo.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 150 citations in OpenAlex.
- Evaluating the role of chemokines and chemokine receptors involved in coronavirus infection.Expert review of clinical immunology · 2022Article
- Single-Cell RNA Sequencing Reveals the Diversity of the Immunological Landscape following Central Nervous System Infection by a Murine Coronavirus.Journal of virology · 2020Article
- Article
- Anosmia in COVID-19: Mechanisms and Significance.Chemical senses · 2020Article
- T cell engagement of cross-presenting microglia protects the brain from a nasal virus infection.Science immunology · 2020Article
- Microglia are required for protection against lethal coronavirus encephalitis in mice.The Journal of clinical investigation · 2018Article
- Role of the inflammasome-related cytokines Il-1 and Il-18 during infection with murine coronavirus.Journal of neurovirology · 2017Article
- Murine Olfactory Bulb Interneurons Survive Infection with a Neurotropic Coronavirus.Journal of virology · 2017Article
- The antiviral cytokine interferon-gamma restricts neural stem/progenitor cell proliferation through activation of STAT1 and modulation of retinoblastoma protein phosphorylation.Journal of neuroscience research · 2017Article
- Interferon gamma modulation of disease manifestation and the local antibody response to alphavirus encephalomyelitis.The Journal of general virology · 2016Article
- The Olfactory Bulb: An Immunosensory Effector Organ during Neurotropic Viral Infections.ACS chemical neuroscience · 2016Review
- Interferon gamma induces protective non-canonical signaling pathways in primary neurons.Journal of neurochemistry · 2015Article
- Promoting remyelination: utilizing a viral model of demyelination to assess cell-based therapies.Expert review of neurotherapeutics · 2014Review
- Review
- Cytokines and olfactory bulb microglia in response to bacterial challenge in the compromised primary olfactory pathway.Journal of neuroinflammation · 2012Article
- CXCR2 signaling and host defense following coronavirus-induced encephalomyelitis.Future virology · 2012Article
- Coronavirus pathogenesis.Advances in virus research · 2011Review
- Pathogenesis of neurotropic murine coronavirus is multifactorial.Trends in pharmacological sciences · 2011Article
- Pathogenesis of murine coronavirus in the central nervous system.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2010Review
- Cell replacement therapies to promote remyelination in a viral model of demyelination.Journal of neuroimmunology · 2010Review
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
To investigate the mechanism by which viruses are cleared from neurons in the central nervous system, we have utilized a mouse model involving infection with a neurotropic variant of mouse hepatitis virus (OBLV60). After intranasal inoculation, OBLV60 grew preferentially in the olfactory bulbs of BALB/c mice. Using in situ hybridization, we found that viral RNA localized primarily in the outer layers of the olfactory bulb, including neurons of the mitral cell layer. Virus was cleared rapidly from the olfactory bulb between 5 and 11 days. Athymic nude mice failed to eliminate the virus, demonstrating a requirement for T lymphocytes. Immunosuppression of normal mice with cyclophosphamide also prevented clearance. Both CD4+ and CD8+ T-cell subsets were important, as depletion of either of these subsets delayed viral clearance. Gliosis and infiltrates of CD4+ and CD8+ cells were detected by immunohistochemical analysis at 6 days. The role of cytokines in clearance was investigated by using an RNase protection assay for interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2, IL-3, IL-4, IL-5, IL-6, tumor necrosis factor alpha (TNF-alpha), TNF-beta, and gamma interferon (IFN-gamma). In immunocompetent mice there was upregulation of RNA for IL-1 alpha, IL-1 beta, IL-6, TNF-alpha, and IFN-gamma at the time of clearance. Nude mice had comparable increases in these cytokine messages, with the exception of IFN-gamma. Induction of major histocompatibility complex class I (MHC-I) molecules on cells in infected brains was demonstrated by immunohistochemical analyses in normal and nude mice, suggesting that IFN-gamma may not be necessary for induction of MHC-I on neural cells in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.