ArticleHistochemistry1994
Identification and classification of interstitial cells in the canine proximal colon by ultrastructure and immunocytochemistry.
Article in Histochemistry, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 56 citations in OpenAlex.
- Emerging diverse roles of telocytes.Development (Cambridge, England) · 2019Review
- Characterization of slow waves generated by myenteric interstitial cells of Cajal of the rabbit small intestine.American journal of physiology. Gastrointestinal and liver physiology · 2015Article
- Interstitial cells: regulators of smooth muscle function.Physiological reviews · 2014Review
- Ca2+ imaging of activity in ICC-MY during local mucosal reflexes and the colonic migrating motor complex in the murine large intestine.The Journal of physiology · 2010Article
- Distribution, development and proliferation of interstitial cells of Cajal in murine colon: an immunohistochemical study from neonatal to adult life.Histochemistry and cell biology · 2010Article
- Characterization of interstitial cells of Cajal in bowel of cattle (Bos taurus).Veterinary research communications · 2006Article
- Myofibroblasts: paracrine cells important in health and disease.Transactions of the American Clinical and Climatological Association · 2000Review
- Characterization of the interstitial cells associated with the submuscular plexus of the guinea-pig colon.Anatomy and embryology · 1996Article
- Morphological changes during ontogeny of the canine proximal colon.Cell and tissue research · 1995Article
- c-kit-dependent development of interstitial cells and electrical activity in the murine gastrointestinal tract.Cell and tissue research · 1995Article
- Immunohistochemical and ultrastructural characteristics of interstitial cells of Cajal in the rabbit duodenum. Presence of a single cilium.Journal of cellular and molecular medicineArticle
- Interstitial cells in the vasculature.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The ultrastructure and immunocytochemistry of interstitial cells (ICs) in the canine proximal colon were investigated. Three types of ICs were found within the tunica muscularis. (1) ICs were located along the submucosal surface of the circular muscle (IC-SM). These cells shared many features of smooth muscle cells, including myosin thick filaments and immunoreactivity to smooth muscle gamma actin, myosin light chain, and calponin antibodies. IC-SM were clearly different from smooth muscle cells in that contractile filaments were less abundant and intermediate filaments consisted of vimentin instead of desmin. (2) ICs in the region of the myenteric plexus (IC-MY) were similar to IC-SM, but these cells had no thick filaments or immunoreactivity to smooth muscle gamma actin or calponin antibodies. (3) The fine structures and immunoreactivity of ICs within the muscle layers (IC-BU) were similar to IC-MY, but IC-BU lacked a definite basal lamina and membrane caveolae. IC-BU and IC-MY were both immunopositive for vimentin. Since all ICs were immunopositive for vimentin, vimentin antibodies may be a useful tool for distinguishing between ICs and smooth muscle cells. Each class of ICs was closely associated with nerve fibers, made specialized contacts with smooth muscle cells, and formed multicellular networks. A combination of ultrastructural and immunocytochemical techniques helps the identification and classification of ICs by revealing the fine structures and determining the "chemical coding" of each class of ICs.
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Registered trials
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