Trial reportDiabetologia1994
Improvement of blood glucose control in IDDM patients retards the progression of morphological changes in early diabetic nephropathy.
Trial report in Diabetologia, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Insulin and glucose-lowering agents for treating people with diabetes and chronic kidney disease.The Cochrane database of systematic reviews · 2018Pooled it
- Continuous subcutaneous insulin infusion (CSII) versus multiple insulin injections for type 1 diabetes mellitus.The Cochrane database of systematic reviews · 2010 · on this mapPooled it
- Continuous subcutaneous insulin infusion versus multiple daily insulin injections in patients with diabetes mellitus: systematic review and meta-analysis.Diabetologia · 2008Pooled it
- Podocyte-specific Nox4 deletion affords renoprotection in a mouse model of diabetic nephropathy.Diabetologia · 2016Article
- Rs12976445 Polymorphism is Associated with Risk of Diabetic Nephropathy Through Modulating Expression of MicroRNA-125 and Interleukin-6R.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- Comparative investigation of kidney mesangial cells from increased oxidative stress-induced diabetic rats by using different microscopy techniques.Molecular and cellular biochemistry · 2014Article
- Urinary excretion of neutrophil gelatinase-associated lipocalin in diabetic rats.Oxidative medicine and cellular longevity · 2014Article
- Diabetic nephropathy and extracellular matrix.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2012Review
- Proteases in Plasma and Kidney of db/db Mice as Markers of Diabetes-Induced Nephropathy.ISRN endocrinology · 2011Article
- The natural progression of kidney injury in young type 1 diabetic patients.Current diabetes reports · 2009Review
- Matrix metalloproteinases in subjects with type 1 diabetes.BMC clinical pathology · 2009Article
- Long-term prevention of diabetic nephropathy: an audit.Diabetologia · 2008Article
- Diabetic nephropathy in children and adolescents.Pediatric nephrology (Berlin, Germany) · 2008Review
- Increased syndecan-1 in serum is related to early nephropathy in type 1 diabetes mellitus patients.Diabetologia · 2006Article
- Follow-up of kidney biopsies in normoalbuminuric patients with type 1 diabetes.Pediatric nephrology (Berlin, Germany) · 2004Article
- Review
- Immunohistochemical colocalization of glycoxidation products and lipid peroxidation products in diabetic renal glomerular lesions. Implication for glycoxidative stress in the pathogenesis of diabetic nephropathy.The Journal of clinical investigation · 1997Article
- A quantitative ultrastructural study of juxtaglomerular arterioles in IDDM patients with micro- and normoalbuminuria.Diabetologia · 1995Article
- Glomerular epithelial foot processes and filtration slits in IDDM patients.Diabetologia · 1995Article
- Blood glucose control and microvascular complications--what do we do now?Diabetologia · 1994Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated in a randomized, prospective study the influence of improved blood glucose control during 2-3 years in young insulin-dependent diabetic (IDDM) patients with microalbuminuria, which is indicative of early nephropathy. Patients were randomized either to intensive treatment by continuous subcutaneous insulin infusion (CSII) (n = 9) or CT (n = 9). Kidney biopsies were taken at baseline and after 26-34 months. End points were structural changes in the glomeruli. Sensitive, quantitative, morphometric methods were used. The blood glucose control improved significantly (p = 0.01) during the study in the CSII-group as glycated haemoglobin (HbA1c) fell from 10.1% ([95% CI] 8.9-11.3) to 8.6% (7.9-9.2), but not in the CT-group, 10.1% (8.3-11.9) vs 9.7% (8.7-10.8). Mean HbA1c during the study period was significantly lower in the CSII-group than in the CT-group, 8.7% (8.1-9.3) vs 9.9% (8.5-11.3), p = 0.04. Basement membrane thickness (BMT) increased in both groups, most (CT vs CSII, p = 0.03) in the CT-group: 140 nm (50-230) vs CSII: 56 nm (27-86). In the CT-group only an increase was seen in matrix/mesangial volume fraction (p = 0.006) and matrix star volume (p = 0.04). Furthermore, a positive correlation between mean HbA1c during the study and change from baseline in BMT (r = 0.70, p = 0.001) and matrix/glomerular volume fraction (r = 0.33, p = 0.09, NS) was demonstrated. Albumin excretion rate correlated significantly to BMT and most of the matrix parameters.(ABSTRACT TRUNCATED AT 250 WORDS)
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.