ArticleVirchows Archiv : an international journal of pathology1994
Expression of transforming growth factor-alpha and its receptor during human liver development and maturation.
Article in Virchows Archiv : an international journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 40 citations in OpenAlex.
- A case of small hepatocellular carcinoma with malignant ductular reaction.International journal of clinical and experimental pathology · 2020Article
- A Retrospective Case Control Study of Ductal Plate Malformation-like Features in Consecutive 200 Autopsies.Pathology oncology research : POR · 2018Article
- Human ductal plate and its derivatives express antigens of cholangiocellular, hepatocellular, hepatic stellate/progenitor cell, stem cell, and neuroendocrine lineages, and proliferative antigens.Experimental biology and medicine (Maywood, N.J.) · 2017Article
- Noninvasive Intracystic Oncocytic Papillary Neoplasm of the Gall Bladder.Journal of gastrointestinal cancer · 2016Article
- Hepatobiliary cystadenocarcinoma of the liver with features of ductal plate malformations.Journal of gastrointestinal cancer · 2015Article
- Combined hepatocellular-cholangiocarcinoma with stem cell features, ductal plate malformation subtype: a case report and proposal of a new subtype.International journal of clinical and experimental pathology · 2013Article
- Human fetal ductal plate revisited: II. MUC1, MUC5AC, and MUC6 are expressed in human fetal ductal plate and MUC1 is expressed also in remodeling ductal plate, remodeled ductal plate and mature bile ducts of human fetal livers.International journal of clinical and experimental pathology · 2013Article
- Ductal plate in hepatoblasts in human fetal livers: I. ductal plate-like structures with cytokeratins 7 and 19 are occasionally seen within human fetal hepatoblasts.International journal of clinical and experimental pathology · 2013Article
- Predicting the F(ab)-mediated effect of monoclonal antibodies in vivo by combining cell-level kinetic and pharmacokinetic modelling.Journal of pharmacokinetics and pharmacodynamics · 2012Article
- Monolobar hepatobiliary fibropolycystic disease.Pathology oncology research : POR · 2011Article
- Liver progenitor cells develop cholangiocyte-type epithelial polarity in three-dimensional culture.Molecular biology of the cell · 2007Article
- Immunocytochemical expression of growth factors by odontogenic jaw cysts.Molecular pathology : MP · 1997Article
- Expression of matrix proteinases during human intrahepatic bile duct development. A possible role in biliary cell migration.The American journal of pathology · 1995Article
- Detection of apoptosis and expression of apoptosis-related proteins during human intrahepatic bile duct development.The American journal of pathology · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated the expression of transforming growth factor-alpha (TGF-alpha) and its receptor during human liver development and maturation, using immunohistochemistry. In the fetal liver, strong immunoreactivity for TGF-alpha and its receptor was noted in intrahepatic bile duct cells of various developmental stages; moderate immunoreactivity for TGF-alpha and mild immunoreactivity for TGF-alpha receptor were found in immature hepatocytes. In the postnatal liver, reactivity for TGF-alpha in hepatocytes decreased gradually and was negative or only weakly positive in the adult liver, while reactivity for TGF-alpha receptor in hepatocytes increased gradually and was strongly positive in the adult liver. In contrast, immunoreactivity of TGF-alpha and its receptor in intrahepatic bile duct cells persisted in the postnatal liver and was positive in the adult liver. These data suggest that the system of TGF-alpha and its receptor has an important role in the proliferation and differentiation of intrahepatic biliary cells and hepatocytes in the fetal liver. The decreasing expression of TGF-alpha in hepatocytes in the postnatal liver may indicate that proliferative activity of hepatocytes gradually decreases with liver maturation. The presence of TGF-alpha and its receptor in intrahepatic bile ducts in the postnatal liver suggests that the system of TGF-alpha and TGF-alpha receptor is operative postnatally.
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