ArticleBulletin of mathematical biology1994
Modelling the dynamics of F-actin in the cell.
Article in Bulletin of mathematical biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 44 citations in OpenAlex.
- Deconvolution Analysis of G and F-Actin Unfolding: Insights into the Thermal Stability and Structural Modifications Induced by PACAP.International journal of molecular sciences · 2025Article
- The role of mode switching in a population of actin polymers with constraints.Journal of mathematical biology · 2021Article
- Dynamic formation of oriented patches in chondrocyte cell cultures.Journal of mathematical biology · 2011Article
- From Physics to Pharmacology?Reports on progress in physics. Physical Society (Great Britain) · 2011Article
- Microfilament orientation constrains vesicle flow and spatial distribution in growing pollen tubes.Biophysical journal · 2009Article
- Models of the collective behavior of proteins in cells: tubulin, actin and motor proteins.Journal of biological physics · 2003Article
- Selecting a common direction. II. Peak-like solutions representing total alignment of cell clusters.Journal of mathematical biology · 1996Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The regulation of the interactions between the actin binding proteins and the actin filaments are known to affect the cytoskeletal structure of F-actin. We develop a model depicting the formation of actin cytoskeleton, bundles and orthogonal networks, via activation or inactivation of different types of actin binding proteins. It is found that as the actin filament density increases in the cell, a spontaneous tendency to organize into bundles or networks occurs depending on the active actin binding protein concentration. Also, a minute change in the relative binding affinity of the actin binding proteins in the cell may lead to a major change in the actin cytoskeleton. Both the linear stability analysis and the numerical results indicate that the structures formed are highly sensitive to changes in the parameters, in particular to changes in the parameter phi, denoting the relative binding affinity and concentration of the actin binding proteins.
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Registered trials
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