Trial reportBritish journal of clinical pharmacology1994
Dose-related effects of ibuprofen on pain-related potentials.
Trial report in British journal of clinical pharmacology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Analgesic effects of propyphenazone in comparison to its combination with caffeine.European journal of clinical pharmacology · 1996Trial
- Effects of azapropazone on pain-related brain activity in human subjects.British journal of clinical pharmacology · 1995Trial
- Effects of flurbiprofen enantiomers on pain-related chemo-somatosensory evoked potentials in human subjects.British journal of clinical pharmacology · 1995Trial
- Effects of peripherally and centrally acting analgesics on somato-sensory evoked potentials.British journal of clinical pharmacology · 1995Trial
- Tonic versus phasic pain: dose-related effects of ketoprofen.European journal of clinical pharmacology · 1995Trial
- The effect of induced optimism on early pain processing: indication by contact heat evoked potentials (CHEPs) and the sympathetic skin response (SSR).Social cognitive and affective neuroscience · 2023Article
- Electroencephalography and analgesics.British journal of clinical pharmacology · 2014Review
- Tonic stimulation of the pharyngeal mucosa causes pain and a reversible increase of inflammatory mediators.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2013Article
- Assessing efficacy of non-opioid analgesics in experimental pain models in healthy volunteers: an updated review.British journal of clinical pharmacology · 2009Review
- Intranasal trigeminal sensitivity in subjects with allergic rhinitis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2006Article
- [Non-steroidal anti-inflammatory drugs (NSAIDs): Antirheumatic, anti-pyretic or analgesic drugs?].Schmerz (Berlin, Germany) · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. The aim of this study was to investigate the dose-related effects of ibuprofen (placebo, 400 and 800 mg rac-ibuprofen [Aktren], administered orally) on experimentally-induced tonic and phasic pain. 2. Eighteen volunteers participated in this randomized, double-blind, three-fold cross-over study. Measurements were obtained before and 90 min after administration of the drugs. Phasic pain was produced by CO2 pulses of two concentrations applied to the right nostril. The left nostril was stimulated with a constant stream of dry air which produced a tonic painful sensation described as dull and burning. Subjects rated the intensity of the painful stimuli by means of visual analogue scales. In addition, chemo-somatosensory event-related potentials (CSSERP) were also recorded in response to phasic painful CO2 stimuli. 3. While mean intensity estimates of both tonic and phasic painful stimuli showed a non-significant dose-related decrease, a statistically significant dose-related decrease was observed for CSSERP amplitudes. 4. In conclusion, in order to investigate analgesic drug effects, CSSERP appear to be a more sensitive measure compared with psychophysically obtained responses.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.