ArticleThe American journal of pathology1994
Origin and fate of oval cells in dipin-induced hepatocarcinogenesis in the mouse.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Who cites it
54 citing papers in PubMed, 172 citations in OpenAlex.
- Triggering Mechanisms of Hepatocyte Repopulation during Liver Regeneration.Biomolecules & therapeutics · 2025Review
- Expression and significance of histone methyltransferase SET domain containing 2 with histone H3 lysine 36 trimethylation in mouse hepatic oval cells differentiated into bile duct epithelial cellsMolecular medicine reports · 2023Article
- Repolarization Precedes Oval Cell-mediated Hepatocytic Regeneration in the CDE Diet Mouse Model.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2022Article
- Innervation of the proximal human biliary tree.Virchows Archiv : an international journal of pathology · 2020Article
- Founder cells for hepatocytes during liver regeneration: from identification to application.Cellular and molecular life sciences : CMLS · 2020Review
- Liver Progenitors and Adult Cell Plasticity in Hepatic Injury and Repair: Knowns and Unknowns.Annual review of pathology · 2020Review
- The diversity and plasticity of adult hepatic progenitor cells and their niche.Liver international : official journal of the International Association for the Study of the Liver · 2017Review
- DNMT1 is a required genomic regulator for murine liver histogenesis and regeneration.Hepatology (Baltimore, Md.) · 2016Article
- Advances in Liver Regeneration: Revisiting Hepatic Stem/Progenitor Cells and Their Origin.Stem cells international · 2016Review
- The methyltransferases enhancer of zeste homolog (EZH) 1 and EZH2 control hepatocyte homeostasis and regeneration.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Contribution of Mature Hepatocytes to Biliary Regeneration in Rats with Acute and Chronic Biliary Injury.PloS one · 2015Article
- Cellular homeostasis and repair in the mammalian liver.Annual review of physiology · 2015Review
- Adult hepatocytes are generated by self-duplication rather than stem cell differentiation.Cell stem cell · 2014Article
- Immunohistochemical characterization of the hepatic progenitor cell compartment in medaka (Oryzias latipes) following hepatic injury.Journal of comparative pathology · 2013Article
- Specific fate decisions in adult hepatic progenitor cells driven by MET and EGFR signaling.Genes & development · 2013Article
- In vitro proliferation and differentiation of hepatic oval cells and their potential capacity for intrahepatic transplantation.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2013Article
- Modeling pathogenesis of primary liver cancer in lineage-specific mouse cell types.Gastroenterology · 2013Article
- Robust cellular reprogramming occurs spontaneously during liver regeneration.Genes & development · 2013Article
- The role of paracrine signals during liver regeneration.Hepatology (Baltimore, Md.) · 2012Article
- Hepatocyte growth factor/c-met signaling is required for stem-cell-mediated liver regeneration in mice.Hepatology (Baltimore, Md.) · 2012Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have studied the development and differentiation of oval cells in the Dipin model of hepatocarcinogenesis in the mouse and compared this process to generation of biliary epithelial cells by bile duct ligation using light and electron microscopy. The Dipin model of hepatocarcinogenesis consists of a single injection of an alkylating drug, Dipin (1,4-bis[N,N'-di(ethylene)-phosphamide]-piperazine), followed by partial hepatectomy. The Dipin treatment resulted in irreversible damage and gradual death of hepatocytes by necrosis and apoptosis. Earlier work provided evidence that regeneration of parenchyma occurred via oval cell proliferation and subsequent differentiation into hepatocytes that replaced the degenerating hepatocytes. Both autoradiographic and morphological data indicated that oval cells were derived from ductular cells of Hering canals. The first oval cells labeled with [3H]thymidine were similar in size and ultrastructure to ductular cells of Hering canals with whom intracellular connections existed. The proliferation of ductular cells of Hering canals gave rise to a new system of oval cell ducts that spread into the liver acinus. In the periportal areas, the transition of oval cells into hepatocytes was observed inside the ducts. Both growth patterns and ultrastructure of oval cells were different from the biliary epithelial cells in bile duct-ligated liver. Also, oval cells retained the property to interact with adjacent hepatocytes through desmosomes and intermediate junctions. Oval cell population was heterogeneous in terms of proliferating potential. A proportion of proliferating cells (38 to 45%) in the Hering canals and small oval cell ducts located in the periportal areas was similar throughout the period of oval cell development. The extent of proliferation of oval cells decreased from 62% at the stage of active migration into the acinus to 22% at maximum formation of oval cell ducts. These data suggest that in the mouse liver cells of the terminal biliary ductules harbor the hepatic stem cell compartment from which oval cells, capable of differentiating into hepatocytes, may be derived.
Indexed as
Identifiers
8053498PMC1887389W67016167What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.