ArticleThe American journal of pathology1994
Organ site-dependent expression of basic fibroblast growth factor in human renal cell carcinoma cells.
Article in The American journal of pathology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 139 citations in OpenAlex.
- Beyond the chaos: How architecture structures tumour biology.The FEBS journal · 2026Review
- Multi-omic profiling of lung and liver tumor microenvironments of metastatic pancreatic cancer reveals site-specific immune regulatory pathways.Genome biology · 2021Article
- The cancer glycocalyx mediates intravascular adhesion and extravasation during metastatic dissemination.Communications biology · 2021Article
- ATP-binding cassette transporters restrict drug delivery and efficacy against brain tumors even when blood-brain barrier integrity is lost.Cell reports. Medicine · 2021Article
- Smac mimetics LCL161 and GDC-0152 inhibit osteosarcoma growth and metastasis in mice.BMC cancer · 2019Article
- Host tissue determinants of tumour immunity.Nature reviews. Cancer · 2019Review
- Tissue-Dependent Tumor Microenvironments and Their Impact on Immunotherapy Responses.Frontiers in immunology · 2018Review
- Review
- Expression of vascular endothelial growth factor and basic fibroblast growth factor in extramammary Paget disease.International journal of clinical and experimental pathology · 2015Article
- A combination treatment with DNA methyltransferase inhibitors and suramin decreases invasiveness of breast cancer cells.Breast cancer research and treatment · 2014Article
- Organ microenvironment affects growth and metastasis of hepatocellular carcinoma via the TGF-β/Smad pathway in mice.Experimental and therapeutic medicine · 2013Article
- Peptides as targeting probes against tumor vasculature for diagnosis and drug delivery.Journal of translational medicine · 2012Review
- Dependence of Wilms tumor cells on signaling through insulin-like growth factor 1 in an orthotopic xenograft model targetable by specific receptor inhibition.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Selection of brain metastasis-initiating breast cancer cells determined by growth on hard agar.The American journal of pathology · 2011Article
- Noninvasive multiparametric imaging of metastasis-permissive microenvironments in a human prostate cancer xenograft.Cancer research · 2009Article
- Animal models of cancer in the head and neck region.Clinical and experimental otorhinolaryngology · 2009Article
- Correlation of bFGF expression in renal cell cancer with clinical and histopathological features by tissue microarray analysis and measurement of serum levels.Journal of cancer research and clinical oncology · 2005Article
- Expression of CXCR1 and CXCR2 receptors in malignant melanoma with different metastatic potential and their role in interleukin-8 (CXCL-8)-mediated modulation of metastatic phenotype.Clinical & experimental metastasis · 2003Article
- Multiparametric in situ mRNA hybridization analysis of gastric biopsies predicts lymph node metastasis in patients with gastric carcinoma.Japanese journal of cancer research : Gann · 2002Article
- Interferons as antiangiogenic agents.Current oncology reports · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
We investigated the influence of organ microenvironment on the angiogenic phenotype in human renal cell carcinoma (HRCC) cells. HRCC line SN12C was established in vitro from a surgical specimen, and metastatic line SN12PM6 was isolated from a lung metastasis produced by parental cells implanted into the kidney of nude mice. SN12C (low metastasis) and SN12PM6 (high metastasis) cells were injected into the kidney or subcutis of nude mice. The kidney tumors were highly vascularized (as revealed by immunohistochemistry using antibodies against factor VIII), and metastatic, whereas the subcutaneous tumors were not. The expression of mRNA for basic fibroblast growth factor (bFGF) in kidney tumors was 10 to 20 times that found in subcutaneous tumors. Similar data were obtained at the protein level by using fluorescence activated cell sorting, immunohistochemistry, and enzyme-linked immunosorbent assay. bFGF was detected in the urine of mice with tumors in the kidney but not subcutaneous tumors. The level of bFGF in the serum of mice with kidney tumors was two to three times that in mice with subcutaneous tumors. The changes in bFGF expression in the tumors was transient. Collectively, these data indicate that the organ microenvironment can influence the expression level of bFGF in HRCC.
Indexed as
Identifiers
8053494PMC1887407W1462105164What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.