ArticleProceedings of the National Academy of Sciences of the United States of America1994
Follicular origin of epidermal papillomas in v-Ha-ras transgenic TG.AC mouse skin.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- A keratin 15 containing stem cell population from the hair follicle contributes to squamous papilloma development in the mouse.Molecular carcinogenesis · 2013Article
- Transgenic overexpression of the proprotein convertase furin enhances skin tumor growth.Neoplasia (New York, N.Y.) · 2012Article
- Cholinergic neural signals to the spleen down-regulate leukocyte trafficking via CD11b.Journal of immunology (Baltimore, Md. : 1950) · 2009Article
- Biological, cellular, and molecular characteristics of an inducible transgenic skin tumor model: a review.Oncogene · 2005Review
- The contribution of epidermal stem cells to skin cancer.Stem cell reviews · 2005Review
- Article
- A definitive role of ornithine decarboxylase in photocarcinogenesis.The American journal of pathology · 2001Article
- Development of keratoacanthomas and squamous cell carcinomas in transgenic rabbits with targeted expression of EJras oncogene in epidermis.The American journal of pathology · 1999Article
- Arsenic enhancement of skin neoplasia by chronic stimulation of growth factors.The American journal of pathology · 1998Article
- Reduced skin tumor development in cyclin D1-deficient mice highlights the oncogenic ras pathway in vivo.Genes & development · 1998Article
- Genetically null mice reveal a central role for epidermal growth factor receptor in the differentiation of the hair follicle and normal hair development.The American journal of pathology · 1997Article
- An estrogen receptor pathway regulates the telogen-anagen hair follicle transition and influences epidermal cell proliferation.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Transgenic mice and squamous multistage skin carcinogenesis.Cancer metastasis reviews · 1995Review
- Keratinocyte stem cells and the targets for nonmelanoma skin cancer.Photochemistry and photobiologyReview
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Authors and funding
2 authors.
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Abstract
A follicular origin for some skin tumors has been hypothesized in both humans and animal models. Because of its rapid and sensitive response to tumor promoter treatment, a v-Ha-ras transgenic (TG.AC) mouse line was used to determine the origins of epidermal papillomas. Using histological studies and transgene expression as a marker for papilloma development, we determined that pedunculated papillomas arose from focal hyperplasias of the permanent portion of the follicular epithelium in phorbol 12-myristate 13-acetate-treated TG.AC mouse skin. Damage to the hair follicle by depilation was also sufficient to induce papillomas that were histologically indistinguishable from those produced by chemical exposure. Identification of the cellular origins of papillomas in this transgenic mouse model will allow for an analysis of the role of the hair follicle and hair cycle-associated signaling in tumor development.
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