ArticleProceedings of the National Academy of Sciences of the United States of America1994
Expression of an activated erythropoietin or a colony-stimulating factor 1 receptor by pluripotent progenitors enhances colony formation but does not induce differentiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 51 citations in OpenAlex.
- Macrophages Orchestrate Hematopoietic Programs and Regulate HSC Function During Inflammatory Stress.Frontiers in immunology · 2020Review
- Progress in detecting cell-surface protein receptors: the erythropoietin receptor example.Annals of hematology · 2014Review
- The effect of erythropoietin on normal and neoplastic cells.Biologics : targets & therapy · 2012Article
- Article
- Cytokine receptors and hematopoietic differentiation.Oncogene · 2007Review
- Retroviral transduction of IL-7Ralpha into IL-7Ralpha-/- bone marrow progenitors: correction of lymphoid deficiency and induction of neutrophilia.Gene therapy · 2005Article
- Growth autonomy and lineage switching in BCR-ABL-transduced human cord blood cells depend on different functional domains of BCR-ABL.Leukemia · 2004Article
- The signaling domain of the erythropoietin receptor rescues prolactin receptor-mutant mammary epithelium.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor.Molecular and cellular biology · 2000Article
- Absence of cytokine receptor-dependent specificity in red blood cell differentiation in vivo.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Control of hematopoietic differentiation: lack of specificity in signaling by cytokine receptors.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Synergistic up-regulation of the myeloid-specific promoter for the macrophage colony-stimulating factor receptor by AML1 and the t(8;21) fusion protein may contribute to leukemogenesis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Isolation of new oncogenic forms of the murine c-fms gene.Journal of virology · 1995Article
- A human GM-CSF receptor expressed in transgenic mice stimulates proliferation and differentiation of hemopoietic progenitors to all lineages in response to human GM-CSF.Molecular biology of the cell · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Whether the presence of specific receptors on the surface of developing cells is the cause or consequence of lineage restriction is not known. If activation of specific receptors is the driving event in differentiation, the premature expression of specific receptors would promote differentiation along that pathway. In this study pluripotent progenitors, obtained from blast cell colonies (pooled or individual) of 5-fluorouracil-treated mice, were infected with retroviral vectors containing either an activated receptor for erythropoietin (EPO), an erythroid progenitor growth factor, or the receptor for colony-stimulating factor 1 (CSF-1), a macrophage growth factor. These receptors exhibit expression patterns restricted to committed progenitors. The developmental potential of infected pluripotent progenitors was not changed, although they expressed the exogenous genes, suggesting that in these cells activation of lineage-specific receptors does not induce differentiation. Acquisition of a constitutively activated EPO receptor allowed erythroid development in mixed colonies in the absence of EPO, as expected. Infection of progenitors with a virus containing the CSF-1 receptor promoted the development of granulocyte/macrophage (GM) colonies but did not alter the differentiation potential of either colony-forming unit (CFU)-GM or CFU-mix.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.