ArticlePflugers Archiv : European journal of physiology1994
H2O2 induced hyperpolarization of pancreatic B-cells.
Article in Pflugers Archiv : European journal of physiology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 44 citations in OpenAlex.
- Redox Balance in Type 2 Diabetes: Therapeutic Potential and the Challenge of Antioxidant-Based Therapy.Antioxidants (Basel, Switzerland) · 2023Review
- ATP-Sensitive Potassium Channels in Migraine: Translational Findings and Therapeutic Potential.Cells · 2022Review
- Differential expression of islet glutaredoxin 1 and 5 with high reactive oxygen species production in a mouse model of diabesity.PloS one · 2017Article
- Does NAD(P)H oxidase-derived H2O2 participate in hypotonicity-induced insulin release by activating VRAC in β-cells?Pflugers Archiv : European journal of physiology · 2012Article
- Expression of transient receptor potential ankyrin 1 (TRPA1) and its role in insulin release from rat pancreatic beta cells.PloS one · 2012Article
- BK channels affect glucose homeostasis and cell viability of murine pancreatic beta cells.Diabetologia · 2011Article
- Oxidative stress and beta-cell dysfunction.Pflugers Archiv : European journal of physiology · 2010Review
- Suppression of KATP channel activity protects murine pancreatic beta cells against oxidative stress.The Journal of clinical investigation · 2009Article
- Mitochondrial reactive oxygen species are obligatory signals for glucose-induced insulin secretion.Diabetes · 2009Article
- Contrasting effects of alloxan on islets and single mouse pancreatic beta-cells.The Biochemical journal · 2000Article
- Interference of H2O2 with stimulus-secretion coupling in mouse pancreatic beta-cells.The Journal of physiology · 1999Article
- The role of cellular hydration in the regulation of cell function.The Biochemical journal · 1996Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Conventional electrophysiology and the whole-cell patch-clamp technique have been applied to elucidate the effects of H2O2 on pancreatic B-cells of the mouse. In these cells, addition of 15 mmol/l glucose leads to depolarization and oscillation of the cell membrane potential. Subsequent addition of H2O2 (1 mmol/l) in the presence of glucose was followed by a marked and rapid hyperpolarization of the cell membrane with suppression of the electrical activity. Accordingly, in slow whole-cell patch-clamp experiments (with nystatin in the pipette solution) H2O2 induced a marked increase of cell membrane conductance. Tolbutamide, a blocker of K+ ATP channels, only partially blocked the effect of H2O2 even at high concentrations. The H2O2-induced, tolbutamide-insensitive current component, however, was largely abolished by a high concentration of TEA+ (80 mmol/l) or BaCl2 (10 mmol/l). It is concluded that in B-cells H2O2 stimulates a K+ current and that this effect leads to marked hyperpolarization and reversal of glucose-induced oscillations of cell membrane potential.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.