ArticleThe Journal of cell biology1994
Actin filament organization in activated mast cells is regulated by heterotrimeric and small GTP-binding proteins.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 134 citations in OpenAlex.
- Cytoskeletal Transport, Reorganization, and Fusion Regulation in Mast Cell-Stimulus Secretion Coupling.Frontiers in cell and developmental biology · 2021Review
- IFT88 influences chondrocyte actin organization and biomechanics.Osteoarthritis and cartilage · 2016Article
- Cytoskeleton in mast cell signaling.Frontiers in immunology · 2012Article
- Thrombin-induced endothelin-1 synthesis and secretion in retinal pigment epithelial cells is rho kinase dependent.Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics · 2010Article
- IgE receptor-mediated alteration of membrane-cytoskeleton interactions revealed by mass spectrometric analysis of detergent-resistant membranes.Biochemistry · 2009Article
- Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling.American journal of physiology. Cell physiology · 2008Article
- The role of actin remodeling in the trafficking of intracellular vesicles, transporters, and channels: focusing on aquaporin-2.Pflugers Archiv : European journal of physiology · 2008Review
- Vibrio parahaemolyticus inhibition of Rho family GTPase activation requires a functional chromosome I type III secretion system.Infection and immunity · 2008Article
- Article
- Constitutive secretion of protease nexin-1 by glial cells and its regulation by G-protein-coupled receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- WIP regulates signaling via the high affinity receptor for immunoglobulin E in mast cells.The Journal of experimental medicine · 2004Article
- The GTP-binding protein RhoA mediates Na,K-ATPase exocytosis in alveolar epithelial cells.Molecular biology of the cell · 2003Article
- Facilitation of Ca(2+)-dependent exocytosis by Rac1-GTPase in bovine chromaffin cells.The Journal of physiology · 2003Article
- Rho1p and Cdc42p act after Ypt7p to regulate vacuole docking.The EMBO journal · 2001Article
- Activated Cdc42/Rac reconstitutes Fcepsilon RI-mediated Ca2+ mobilization and degranulation in mutant RBL mast cells.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
- ATP-dependent membrane assembly of F-actin facilitates membrane fusion.Molecular biology of the cell · 2001Article
- Cdc42 and Rac stimulate exocytosis of secretory granules by activating the IP(3)/calcium pathway in RBL-2H3 mast cells.The Journal of cell biology · 2000Article
- Selective alterations in biosynthetic and endocytic protein traffic in Madin-Darby canine kidney epithelial cells expressing mutants of the small GTPase Rac1.Molecular biology of the cell · 2000Article
- Rac-1 regulates nuclear factor of activated T cells (NFAT) C1 nuclear translocation in response to Fcepsilon receptor type 1 stimulation of mast cells.The Journal of experimental medicine · 1998Article
- Fluid-phase markers in the basolateral endocytic pathway accumulate in response to the actin assembly-promoting drug Jasplakinolide.Molecular biology of the cell · 1998Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Rat peritoneal mast cells, both intact and permeabilized, have been used widely as model secretory cells. GTP-binding proteins and calcium play a major role in controlling their secretory response. Here we have examined changes in the organization of actin filaments in intact mast cells after activation by compound 48/80, and in permeabilized cells after direct activation of GTP-binding proteins by GTP-gamma-S. In both cases, a centripetal redistribution of cellular F-actin was observed: the content of F-actin was reduced in the cortical region and increased in the cell interior. The overall F-actin content was increased. Using permeabilized cells, we show that AIF4-, an activator of heterotrimeric G proteins, induces the disassembly of F-actin at the cortex, while the appearance of actin filaments in the interior of the cell is dependent on two small GTPases, rho and rac. Rho was found to be responsible for de novo actin polymerization, presumably from a membrane-bound monomeric pool, while rac was required for an entrapment of the released cortical filaments. Thus, a heterotrimeric G-protein and the small GTPases, rho and rac, participate in affecting the changes in the actin cytoskeleton observed after activation of mast cells.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.