ArticleJournal of bacteriology1994
Characterization of aarA, a pleiotrophic negative regulator of the 2'-N-acetyltransferase in Providencia stuartii.
Article in Journal of bacteriology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 44 citations in OpenAlex.
- Rhomboid proteases: key players at the cell surface within haloarchaea.Frontiers in microbiology · 2025Article
- Activity-based probes for rhomboid proteases discovered in a mass spectrometry-based assay.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- The rhomboid protease family: a decade of progress on function and mechanism.Genome biology · 2011Review
- Rhomboid homologs in mycobacteria: insights from phylogeny and genomic analysis.BMC microbiology · 2010Article
- Sequence-specific intramembrane proteolysis: identification of a recognition motif in rhomboid substrates.Molecular cell · 2009Article
- Making the cut: central roles of intramembrane proteolysis in pathogenic microorganisms.Nature reviews. Microbiology · 2009Review
- Rhomboid protease AarA mediates quorum-sensing in Providencia stuartii by activating TatA of the twin-arginine translocase.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Functional characterization of Escherichia coli GlpG and additional rhomboid proteins using an aarA mutant of Providencia stuartii.Journal of bacteriology · 2006Article
- Expression of a novel gene, gluP, is essential for normal Bacillus subtilis cell division and contributes to glucose export.BMC microbiology · 2004Article
- The rhomboids: a nearly ubiquitous family of intramembrane serine proteases that probably evolved by multiple ancient horizontal gene transfers.Genome biology · 2003Article
- Overexpression and characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii.Antimicrobial agents and chemotherapy · 2001Article
- Identification and characterization of the point mutation which affects the transcription level of the chromosomal 3-N-acetyltransferase gene of Streptomyces griseus SS-1198.Antimicrobial agents and chemotherapy · 2000Article
- Providencia stuartii genes activated by cell-to-cell signaling and identification of a gene required for production or activity of an extracellular factor.Journal of bacteriology · 1999Article
- Activation of the 2'-N-acetyltransferase gene [aac(2')-Ia] in Providencia stuartii by an interaction of AarP with the promoter region.Antimicrobial agents and chemotherapy · 1999Article
- Mutations in aarE, the ubiA homolog of Providencia stuartii, result in high-level aminoglycoside resistance and reduced expression of the chromosomal aminoglycoside 2'-N-acetyltransferase.Antimicrobial agents and chemotherapy · 1998Article
- Identification and characterization of aarF, a locus required for production of ubiquinone in Providencia stuartii and Escherichia coli and for expression of 2'-N-acetyltransferase in P. stuartii.Journal of bacteriology · 1998Article
- An extracellular factor regulating expression of the chromosomal aminoglycoside 2'-N-acetyltransferase of Providencia stuartii.Antimicrobial agents and chemotherapy · 1997Article
- Characterization of gentamicin 2'-N-acetyltransferase from Providencia stuartii: its use of peptidoglycan metabolites for acetylation of both aminoglycosides and peptidoglycan.Journal of bacteriology · 1997Article
- aarC, an essential gene involved in density-dependent regulation of the 2'-N-acetyltransferase in Providencia stuartii.Journal of bacteriology · 1997Article
- Characterization of the chromosomal aminoglycoside 2'-N-acetyltransferase gene from Mycobacterium fortuitum.Antimicrobial agents and chemotherapy · 1996Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have utilized transposon mutagenesis to obtain insertional mutations in Providencia stuartii that activate the chromosomal aac(2')-la gene. Two closely linked mini-Tn5Cm insertions were obtained in a locus designated aarA, and a single insertion was obtained in a separate locus, aarC. Nucleotide sequence analysis, complementation studies, and localization of the sites of mini-Tn5Cm insertion have allowed the identification of the aarA coding region. The deduced AarA protein had a molecular mass of 31,086 kDa and displayed characteristics of an integral membrane protein. A strain deleted for the aarA gene by allelic exchange showed at least a fourfold increase in the accumulation of aac(2')-la mRNA and an eightfold increase in aminoglycoside resistance. Mutations in aarA were pleiotrophic and also resulted in loss of pigmentation and a deficiency in cell separation during division.
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