Evidence map›Paper›PMID 8050359›Full record

ArticleDevelopment (Cambridge, England)1994

Developmental control of a G1-S transcriptional program in Drosophila.

R J Duronio, P H O'Farrell

Open access · greenAbstract read
In one paragraph

Article in Development (Cambridge, England), 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 113 citations in OpenAlex.

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  10. Quiescence: early evolutionary origins and universality do not imply uniformity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2011
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

R J DuronioDepartment of Biochemistry and Biophysics, University of California, San Francisco 94143.
P H O'Farrell
University of California, San Francisco · US

Funding

MOLECULAR DETERMINANTS OF DEVELOPMENTAL FATER01GM037193 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI O'FARRELL, PATRICK H · 1986 to 2009
$4.4M
STRUCTURE ANALYSIS OF PROTEINS INVOLVED IN CARDIOVASCULAR FUNCTION/DEVELOPMENTP01HL043821 · NHLBI · UNIVERSITY OF CALIFORNIA SAN FRANCISCO · PI ORDAHL, CHARLES P · 1989 to 1996
–
NHLBI NIH HHS P01 HL 43821NIGMS NIH HHS R01 GM037193
6 · The paper itself

Abstract

We have defined a coordinate program of transcription of S-phase genes (DNA polymerase alpha, PCNA and the two ribonucleotide reductase subunits) that can be induced by the G1 cyclin, cyclin E. In Drosophila embryos, this program drives an intricate spatial and temporal pattern of gene expression that perfectly parallels the embryonic program of S-phase control. This dynamic pattern of expression is not disrupted by a mutation, string, that blocks the cell cycle. Thus, the transcriptional program is not a secondary consequence of cell cycle progression. We suggest that developmental signals control this transcriptional program and that its activation either directly or indirectly drives transition from G1 to S phase in the stereotyped embryonic pattern.

Indexed as

Transcription, GeneticAmino Acid SequenceAnimalsBase SequenceDNA ProbesDrosophilaG1 PhaseGene ExpressionHumansIn Situ HybridizationMiceMolecular Sequence DataSaccharomycesSequence AlignmentS PhaseVaccinia virusDNA Probes

Identifiers

PMID8050359
PMCPMC2753441
OpenAlexW2191115168

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.