ArticleClinical and experimental immunology1994
IgE elevation and IgE anti-malarial antibodies in Plasmodium falciparum malaria: association of high IgE levels with cerebral malaria.
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 131 citations in OpenAlex.
- Are humanized IgE reporter systems potential game changers in serological diagnosis of human parasitic infection?Parasitology research · 2022Article
- Plasmodium falciparum and Helminth Coinfections Increase IgE and Parasite-Specific IgG Responses.Microbiology spectrum · 2021Article
- Activation of Mast Cells PromoteFrontiers in cellular and infection microbiology · 2019Article
- A STAT6 Intronic Single-Nucleotide Polymorphism is Associated with Clinical Malaria in Ghanaian Children.Genetics & epigenetics · 2016Article
- Article
- Comparative immune study on cutaneous leishmaniasis patients with single and multiple sores.Journal of parasitic diseases : official organ of the Indian Society for Parasitology · 2015Article
- Genotype combinations of two IL4 polymorphisms influencing IL-4 plasma levels are associated with different risks of severe malaria in the Malian population.Immunogenetics · 2015Article
- Chemokine levels and parasite- and allergen-specific antibody responses in children and adults with severe or uncomplicated Plasmodium falciparum malaria.European journal of microbiology & immunology · 2015Article
- Mast cell activation in the skin of Plasmodium falciparum malaria patients.Malaria journal · 2015Article
- Determinants of infant susceptibility to malaria during the first year of life in South Western cameroon.Open forum infectious diseases · 2015Article
- Glucose-6-phosphate dehydrogenase polymorphisms and susceptibility to mild malaria in Dogon and Fulani, Mali.Malaria journal · 2014Article
- IgE- and IgG mediated severe anaphylactic platelet transfusion reaction in a known case of cerebral malaria.Asian journal of transfusion science · 2013Article
- Asthma and atopic dermatitis are associated with increased risk of clinical Plasmodium falciparum malaria.BMJ open · 2013Article
- Enhanced basophil reactivities during severe malaria and their relationship with the Plasmodium falciparum histamine-releasing factor translationally controlled tumor protein.Infection and immunity · 2012Article
- Impact of mosquito bites on asexual parasite density and gametocyte prevalence in asymptomatic chronic Plasmodium falciparum infections and correlation with IgE and IgG titers.Infection and immunity · 2012Article
- The complexities of malaria disease manifestations with a focus on asymptomatic malaria.Malaria journal · 2012Review
- IL-4 haplotype -590T, -34T and intron-3 VNTR R2 is associated with reduced malaria risk among ancestral indian tribal populations.PloS one · 2012Article
- Critical role of the neutrophil-associated high-affinity receptor for IgE in the pathogenesis of experimental cerebral malaria.The Journal of experimental medicine · 2011Article
- Evidence for a peak shift in a humoral response to helminths: age profiles of IgE in the Shuar of Ecuador, the Tsimane of Bolivia, and the U.S. NHANES.PLoS neglected tropical diseases · 2011Article
- Polymorphisms in the RNASE3 gene are associated with susceptibility to cerebral malaria in Ghanaian children.PloS one · 2011Article
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the course of studying immunoregulation in human Plasmodium falciparum malaria we have investigated IgE levels and IgE anti-plasmodial antibodies in children and adults from areas of high malaria endemicity in both Africa and Asia. On average, 85% of all donors had significantly elevated levels of total IgE. A fraction of the IgE had anti-plasmodial activity as revealed by ELISA with lysates of infected erythrocytes as antigen. Using synthetic peptides representing antigenic regions of two major plasmodial blood stage antigens, IgE antibody concentrations ranged from 5 to 15 ng/ml serum for each of the peptides. On average, the concentrations of the corresponding IgG antibodies were x 500-1000 higher. Immunoblotting of parasite lysates showed that most donors had IgE antibodies against one or several of a restricted number of plasmodial polypeptides, with antibodies against an antigen of mol.wt 45 kD already being present in all donors at an early age. Donors having IgE antibodies to particular antigens also frequently had corresponding IgG4 antibodies, reflecting underlying IL-4-dependent cellular mechanisms controlling formation of these isotypes. As infection with other parasites such as helminths is known to induce IgE elevation, the results do not prove that plasmodial infections were the primary cause of IgE induction. However, the importance of plasmodial infection for IgE elevation was supported by the finding of significantly higher levels of IgE, but not of IgG, in children with cerebral malaria compared with patients with uncomplicated disease.
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