ArticleThe Journal of cell biology1994
Molecular motors are differentially distributed on Golgi membranes from polarized epithelial cells.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
60 citing papers in PubMed, 203 citations in OpenAlex.
- Organization of a cytoskeletal superstructure in the apical domain of intestinal tuft cells.The Journal of cell biology · 2024Article
- Doublecortin facilitates the elongation of the somatic Golgi apparatus into proximal dendrites.Molecular biology of the cell · 2021Article
- Fluorescence microscopy applied to intracellular transport by microtubule motors.Journal of biosciences · 2018Review
- Review
- Myosin-I molecular motors at a glance.Journal of cell science · 2016Review
- The guanine exchange factor Gartenzwerg and the small GTPase Arl1 function in the same pathway with Arfaptin during synapse growth.Biology open · 2015Article
- Gathering up meiotic telomeres: a novel function of the microtubule-organizing center.Cellular and molecular life sciences : CMLS · 2014Review
- Article
- Hooks and comets: The story of microtubule polarity orientation in the neuron.Developmental neurobiology · 2011Review
- Calmodulin dissociation regulates Myo5 recruitment and function at endocytic sites.The EMBO journal · 2010Article
- Regulation of intestinal epithelial cells transcriptome by enteric glial cells: impact on intestinal epithelial barrier functions.BMC genomics · 2009Article
- Dynein drives nuclear rotation during forward progression of motile fibroblasts.Journal of cell science · 2008Article
- Regulatory dissociation of Tctex-1 light chain from dynein complex is essential for the apical delivery of rhodopsin.Traffic (Copenhagen, Denmark) · 2006Article
- A methionine synthase homolog is associated with secretory vesicles in tobacco pollen tubes.Planta · 2005Article
- Myosin-1a is critical for normal brush border structure and composition.Molecular biology of the cell · 2005Article
- A role for myosin-1A in the localization of a brush border disaccharidase.The Journal of cell biology · 2004Article
- Loss of myosin VI reduces secretion and the size of the Golgi in fibroblasts from Snell's waltzer mice.The EMBO journal · 2003Article
- Myosin motors and not actin comets are mediators of the actin-based Golgi-to-endoplasmic reticulum protein transport.Molecular biology of the cell · 2003Article
- In vitro assays demonstrate that pollen tube organelles use kinesin-related motor proteins to move along microtubules.The Plant cell · 2003Article
- Human tastin, a proline-rich cytoplasmic protein, associates with the microtubular cytoskeleton.The Biochemical journal · 2002Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Microtubules (MT) are required for the efficient transport of membranes from the trans-Golgi and for transcytosis of vesicles from the basolateral membrane to the apical cytoplasm in polarized epithelia. MTs in these cells are primarily oriented with their plus ends basally near the Golgi and their minus-ends in the apical cytoplasm. Here we report that isolated Golgi and Golgi-enriched membranes from intestinal epithelial cells possess the actin based motor myosin-I, the MT minus-end-directed motor cytoplasmic dynein and its in vitro motility activator dynactin (p150/Glued). The Golgi can be separated into stacks, possessing features of the Golgi cisternae, and small membranes enriched in the trans-Golgi network marker TGN 38/41. Whereas myosin-I is present on all membranes in the Golgi fraction, dynein is present only on the small membrane fraction. Dynein, like myosin-I, is associated with membranes as a cytoplasmic peripheral membrane protein. Dynein and myosin-I coassociate with membranes that bind to MTs and cross-link actin filaments and MTs in a nucleotide-dependent manner. We propose that cytoplasmic dynein moves Golgi membranes along MTs to the cell cortex where myosin-I provides local delivery through the actin-rich cytoskeleton to the apical membrane.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.