ArticleImmunology1994
Ca2+ oscillations in neutrophils triggered by immune complexes result from Ca2+ influx.
Article in Immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 17 citations in OpenAlex.
- Oscillatory NAD(P)H waves and calcium oscillations in neutrophils? A modeling study of feasibility.Biophysical journal · 2009Article
- Recombinant apoaequorin acting as a pseudo-luciferase reports micromolar changes in the endoplasmic reticulum free Ca2+ of intact cells.The Biochemical journal · 1996Article
- Altered Ca2+ signalling in human neutrophils from inflammatory sites.Annals of the rheumatic diseases · 1994Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although the mechanisms of Ca2+ signalling in neutrophils by certain chemotactic agents have been well characterized, the signalling by immune complexes is poorly understood. Here we demonstrate that immune complex stimulation, acting via Fc receptors, leads to repetitive Ca2+ spiking in neutrophils. Although the initial Ca2+ rise was the result of release of Ca2+ from intracellular stores, subsequent repetitive Ca2+ spikes resulted from transmembrane influx, as they were prevented by removal of extracellular Ca2+ and were accompanied by Mn2+ influx. The transmembrane Ca2+ spikes induced dramatic neutrophil cell shape changes. The Ca2+ spiking phase was inhibited by a phospholipase C (PLC) inhibitor, U73122, and removal of immune complex, but not by cytochalasin B. It was concluded that Ca2+ spiking was dependent upon the initial release of Ca2+ from an intracellular Ca2+ store, and driven by continued binding of immune complex, which triggered pulsatile changes in transmembrane influx.
Indexed as
Identifiers
8045594PMC1414847W1785714384What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.