ArticleProceedings of the National Academy of Sciences of the United States of America1994
KAR3-encoded kinesin is a minus-end-directed motor that functions with centromere binding proteins (CBF3) on an in vitro yeast kinetochore.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
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Who cites it
46 citing papers in PubMed, 83 citations in OpenAlex.
- The kinesin Kar3 is required for endoplasmic reticulum-associated degradation.Molecular biology of the cell · 2025Article
- Cik1 and Vik1 accessory proteins confer distinct functions to the kinesin-14 Kar3.Journal of cell science · 2023Article
- The EB1-Kinesin-14 complex is required for efficient metaphase spindle assembly and kinetochore bi-orientation.The Journal of cell biology · 2020Article
- Mislocalization of TORC1 to Lysosomes Caused by KIF11 Inhibition Leads to Aberrant TORC1 Activity.Molecules and cells · 2020Article
- Article
- Minus-end-directed Kinesin-14 motors align antiparallel microtubules to control metaphase spindle length.Developmental cell · 2014Article
- Function of Cryptococcus neoformans KAR7 (SEC66) in karyogamy during unisexual and opposite-sex mating.Eukaryotic cell · 2012Article
- Design features of a mitotic spindle: balancing tension and compression at a single microtubule kinetochore interface in budding yeast.Annual review of genetics · 2008Review
- Analysis of kinesin motor function at budding yeast kinetochores.The Journal of cell biology · 2006Article
- Cik1 targets the minus-end kinesin depolymerase kar3 to microtubule plus ends.Current biology : CB · 2005Article
- Mechanistic analysis of the Saccharomyces cerevisiae kinesin Kar3.The Journal of biological chemistry · 2004Article
- S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion.Molecular biology of the cell · 2004Article
- Genetic evidence for a role of phospholipase C at the budding yeast kinetochore.Molecular genetics and genomics : MGG · 2003Article
- Simple centromere, complex kinetochore: linking spindle microtubules and centromeric DNA in budding yeast.The Journal of cell biology · 2002Review
- pkl1(+)and klp2(+): Two kinesins of the Kar3 subfamily in fission yeast perform different functions in both mitosis and meiosis.Molecular biology of the cell · 2001Article
- The spindle checkpoint of the yeast Saccharomyces cerevisiae requires kinetochore function and maps to the CBF3 domain.Genetics · 2001Article
- Novel roles for saccharomyces cerevisiae mitotic spindle motors.The Journal of cell biology · 1999Article
- Slk19p is a centromere protein that functions to stabilize mitotic spindles.The Journal of cell biology · 1999Article
- Differential regulation of the Kar3p kinesin-related protein by two associated proteins, Cik1p and Vik1p.The Journal of cell biology · 1999Article
- Microtubule dynamics from mating through the first zygotic division in the budding yeast Saccharomyces cerevisiae.The Journal of cell biology · 1999Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
We have used in vitro motility assays to investigate the mechanism of kinetochore function in the budding yeast Saccharomyces cerevisiae. Functional centromeric DNA plus a tripartite centromere binding protein complex, CBF3, was found to be necessary but not sufficient for in vitro kinetochore activity. A fourth required component was identified as the motor protein Kar3p, a previously reported yeast kinesin known to be involved in karyogamy and mitosis. Our data support genetic evidence suggesting that Kar3p is a kinetochore-associated motor and imply that CBF3 plays a regulatory role in kinetochore function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.