ArticleProceedings of the National Academy of Sciences of the United States of America1994
Mutations in ras genes in cells cultured from mouse skin tumors induced by ultraviolet irradiation.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 38 citations in OpenAlex.
- K-ras oncogene mutation in pterygium.Eye (London, England) · 2017Trial
- Review
- P16 UV mutations in human skin epithelial tumors.Oncogene · 1999Article
- The (6-4) photoproduct of thymine-thymine induces targeted substitution mutations in mammalian cells.Nucleic acids research · 1998Article
- Relevance of ultraviolet-induced N-ras oncogene point mutations in development of primary human cutaneous melanoma.The American journal of pathology · 1996Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations in ras oncogenes were detected in cultured cells of mouse skin tumors induced by near-UV irradiation. DNA extracted from the UV-induced tumor cells was transfected to golden hamster embryo cells, and focus-forming ability was confirmed in 22 of 26 cell strains, 15 of which had the repetitive mouse sequence. Mouse ras genes were detected in 10 of these 22 cell strains. Point mutations in the ras genes were at Ha-ras codon 13 (GGC-->GTC in two strains, GGC-->AGC in one strain), Ki-ras codon 61 (CAA-->GAA in two strains), and N-ras codon 61 (CAA-->CAT in two strains, CAA-->AAA in two strains). In one tumor cell strain no base change was directed. Most mutations occurred at dipyrimidine sites. Pyrimidine dimers or pyrimidine(6-4)pyrimidone photoproducts are the likely cause of the skin cancers. The base change occurred preferentially at G.C base pairs, and transversions predominated.
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