ArticleProceedings of the National Academy of Sciences of the United States of America1994
Piebald lethal (sl) acts early to disrupt the development of neural crest-derived melanocytes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
32 citing papers in PubMed, 141 citations in OpenAlex.
- Endothelin signaling in development.Development (Cambridge, England) · 2023Review
- Genome-Wide Association Study for Screening and Identifying Potential Shin Color Loci in Ducks.Genes · 2022Article
- The Arp2/3 complex is crucial for colonisation of the mouse skin by melanoblasts.Development (Cambridge, England) · 2020Article
- A 14-bp insertion in endothelin receptor B-like (EDNRB2) is associated with white plumage in Chinese geese.BMC genomics · 2020Article
- Article
- Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Article
- Specification of neural crest into sensory neuron and melanocyte lineages.Developmental biology · 2012Review
- Article
- Article
- Roles of endothelin signaling in melanocyte development and melanoma.Pigment cell & melanoma research · 2010Review
- p38 regulates pigmentation via proteasomal degradation of tyrosinase.The Journal of biological chemistry · 2010Article
- Melanocytes in development and cancer.Journal of cellular physiology · 2010Review
- Not just black and white: pigment pattern development and evolution in vertebrates.Seminars in cell & developmental biology · 2009Review
- A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy.Human molecular genetics · 2008Article
- The secreted metalloprotease ADAMTS20 is required for melanoblast survival.PLoS genetics · 2008Article
- Genetic evidence does not support direct regulation of EDNRB by SOX10 in migratory neural crest and the melanocyte lineage.Mechanisms of development · 2006Article
- Effects of G-protein mutations on skin color.Nature genetics · 2004Article
- Melanocytes and pigmentation are affected in dopachrome tautomerase knockout mice.Molecular and cellular biology · 2004Article
- The importance of having your SOX on: role of SOX10 in the development of neural crest-derived melanocytes and glia.Oncogene · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mice homozygous for the piebald lethal (sl) mutation have a predominantly white coat due to the absence of neural crest-derived melanocytes in the hair follicles. To investigate the time in embryonic development when the s1 gene affects the melanocyte lineage, we compared the distribution of melanocyte precursors in wild-type and mutant embryos, using an antibody specific for tyrosinase-related protein 2 (TRP-2). TRP-2 positive cells were first observed adjacent to the anterior cardinal vein in 10.5-day postcoitem wild-type embryos. From 11.5 to 13.5 days postcoitem, there was a nonuniform distribution of TRP-2 positive cells along the anterior-posterior axis, with the highest density of cells in the head and tail regions. Along the dorsal-ventral axis, the cells were restricted to positions lateral, but never dorsal, to the neural tube. In homozygous sl/sl embryos TRP-2 staining was restricted to the non-neural crest-derived melanocytes of the pigmented retinal epithelium and the telencephalon. Few positive cells were seen in areas that will form neural crest-derived melanocytes in the inner ear, skin, hair follicles, leg musculature, or heart. We conclude that the piebald lethal mutation acts prior to the onset of TRP-2 expression to disrupt the development of neural crest-derived melanocytes. The non-uniform distribution of melanoblasts in wild-type mice suggests that piebald acts stochastically to affect melanocyte development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.