ArticleThe Journal of clinical investigation1994
Altered activity of the system A amino acid transporter in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women.
Article in The Journal of clinical investigation, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.
- Placental expression and activity of system A and system L amino acid transporters in pregnancies complicated by diabetes mellitus and fetal growth disorders: a systematic review.Frontiers in endocrinology · 2026Pooled it
- Maternal-fetal cross-talk via the placenta: influence on offspring development and metabolism.Development (Cambridge, England) · 2023Review
- The Association between Macrosomia and Amino Acids' Levels in Maternal and Cord Sera: A Case-Control Study.Nutrients · 2023Article
- Expression of nutrient transporters in placentas affected by gestational diabetes: role of leptin.Frontiers in endocrinology · 2023Review
- Developmental origins of metabolic diseases.Physiological reviews · 2021Review
- Review
- Downregulation of Placental Amino Acid Transporter Expression and mTORC1 Signaling Activity Contributes to Fetal Growth Retardation in Diabetic Rats.International journal of molecular sciences · 2020Article
- Vasoactive Intestinal Peptide induces glucose and neutral amino acid uptake through mTOR signalling in human cytotrophoblast cells.Scientific reports · 2019Article
- Maternal diet modulates placental nutrient transporter gene expression in a mouse model of diabetic pregnancy.PloS one · 2019Article
- Positive regulation of placentation by L-amino acid transporter-1 (lat1) in pregnant mice.International journal of clinical and experimental pathology · 2017Article
- Placental Nutrient Transport in Gestational Diabetic Pregnancies.Frontiers in endocrinology · 2017Review
- Increased placental nutrient transport in a novel mouse model of maternal obesity with fetal overgrowth.Obesity (Silver Spring, Md.) · 2015Article
- Expression and functional characterisation of System L amino acid transporters in the human term placenta.Reproductive biology and endocrinology : RB&E · 2015Article
- Integration of computational modeling with membrane transport studies reveals new insights into amino acid exchange transport mechanisms.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- The role of placental nutrient sensing in maternal-fetal resource allocation.Biology of reproduction · 2014Review
- Maternal-fetal nutrient transport in pregnancy pathologies: the role of the placenta.International journal of molecular sciences · 2014Review
- Immunohistochemical distribution of cell cycle proteins p27, p57, cyclin D3, PCNA and Ki67 in normal and diabetic human placentas.Journal of molecular histology · 2014Article
- L-methionine placental uptake: characterization and modulation in gestational diabetes mellitus.Reproductive sciences (Thousand Oaks, Calif.) · 2013Article
- Role of placental nutrient sensing in developmental programming.Clinical obstetrics and gynecology · 2013Review
- Placental transport in response to altered maternal nutrition.Journal of developmental origins of health and disease · 2013Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fetal macrosomia (FM) is a well-recognized complication of diabetic pregnancy but it is not known whether placental transport mechanisms are altered. We therefore studied the activity of the system A amino acid transporter, the system L amino acid transporter, and the Na+/H+ exchanger in microvillous membrane vesicles from placentas of macrosomic babies born to diabetic women (FM group), from placentas of appropriately grown babies born to diabetic women (appropriate for gestational age group) and from placentas of appropriately grown babies of normal women (control group). Sodium-dependent uptake of [14C]-methylaminoisobutyric acid at 30 s (initial rate, a measure of system A activity) was 49% lower into FM vesicles than into control vesicles (P < 0.02); this effect was due to a decrease in Vmax of the transporter with no change in Km. There was no significant difference in system A activity between the appropriate for gestational age group and control or FM group. There was also no difference between system L transporter or Na+/H+ exchanger activity between the three groups. We conclude that the number of system A transporters per milligram of membrane protein in the placental microvillous membrane is selectively reduced in diabetic pregnancies associated with FM.
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Registered trials
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