ArticleBiophysical journal1994
Calcium-dependent inactivation of L-type calcium channels in planar lipid bilayers.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 64 citations in OpenAlex.
- Spreading depolarizations pose critical energy challenges in acute brain injury.Journal of neurochemistry · 2024Review
- Activation of mGluR1 negatively modulates glutamate-induced phase shifts of the circadian pacemaker in the mouse suprachiasmatic nucleus.Neurobiology of sleep and circadian rhythms · 2023Article
- The Calcium Signaling Mechanisms in Arterial Smooth Muscle and Endothelial Cells.Comprehensive Physiology · 2021Article
- Mitochondrial CaMolecules and cells · 2020Article
- L-type CaJournal of physiology and biochemistry · 2019Article
- Ionic currents influencing spontaneous firing and pacemaker frequency in dopamine neurons of the ventrolateral periaqueductal gray and dorsal raphe nucleus (vlPAG/DRN): A voltage-clamp and computational modelling study.Journal of computational neuroscience · 2017Article
- A novel calmodulin site in the Cav1.2 N-terminus regulates calcium-dependent inactivation.Pflugers Archiv : European journal of physiology · 2014Article
- Analysis of factors affecting Ca(2+)-dependent inactivation dynamics of L-type Ca(2+) current of cardiac myocytes in pulmonary vein of rabbit.The Journal of physiology · 2012Article
- Different subcellular populations of L-type Ca2+ channels exhibit unique regulation and functional roles in cardiomyocytes.Journal of molecular and cellular cardiology · 2012Review
- Intracellular Ca2+ silences L-type Ca2+ channels in mesenteric veins: mechanism of venous smooth muscle resistance to calcium channel blockers.Circulation research · 2010Article
- Caffeine-induced immobilization of gating charges in isolated guinea-pig ventricular heart cells.British journal of pharmacology · 2002Article
- Regulation of ion channels in myocardial cells and protection of ischemic myocardium.Heart failure reviews · 2000Review
- Caffeine-sensitive calcium stores regulate synaptic transmission from retinal rod photoreceptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Mutations in the EF-hand motif impair the inactivation of barium currents of the cardiac alpha1C channel.Biophysical journal · 1998Article
- Effect of bay K 8644 (-) and the beta2a subunit on Ca2+-dependent inactivation in alpha1C Ca2+ channels.The Journal of general physiology · 1998Article
- Intracellular Ca2+ inhibits smooth muscle L-type Ca2+ channels by activation of protein phosphatase type 2B and by direct interaction with the channel.The Journal of general physiology · 1997Article
- Structural regions of the cardiac Ca channel alpha subunit involved in Ca-dependent inactivation.The Journal of general physiology · 1997Article
- Intracellular Ca2+ inactivates L-type Ca2+ channels with a Hill coefficient of approximately 1 and an inhibition constant of approximately 4 microM by reducing channel's open probability.Biophysical journal · 1997Article
- Ca2+- and voltage-dependent inactivation of Ca2+ channels in nerve terminals of the neurohypophysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
- Calcium signaling in transgenic mice overexpressing cardiac Na(+)-Ca2+ exchanger.The Journal of general physiology · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Intracellular Ca2+ can inhibit the activity of voltage-gated Ca channels by modulating the rate of channel inactivation. Ca(2+)-dependent inactivation of these channels may be a common negative feedback process important for regulating Ca2+ entry under physiological and pathological conditions. This article demonstrates that the inactivation of cardiac L-type Ca channels, reconstituted into planar lipid bilayers and studied in the presence of a dihydropyridine agonist, is sensitive to Ca2+. The rates and extents of inactivation, determined from ensemble averages of unitary Ba2+ currents, decreased when the calcium concentration facing the intracellular surface of the channel ([Ca2+]i) was lowered from approximately 10 microM to 20 nM by the addition of Ca2+ chelators. The rates and extents of Ba2+ current inactivation could also be increased by subsequent addition of Ca2+ raising the [Ca2+]i to 15 microM, thus demonstrating that the Ca2+ dependence of inactivation could be reversibly regulated by changes in [Ca2+]i. In addition, reconstituted Ca channels inactivated more quickly when the inward current was carried by Ca2+ than when it was carried by Ba2+, suggesting that local increases in [Ca2+]i could activate Ca(2+)-dependent inactivation. These data support models in which Ca2+ binds to the channel itself or to closely associated regulatory proteins to control the rate of channel inactivation, and are inconsistent with purely enzymatic models for channel inactivation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.