ArticleBiophysical journal1994
Multiphasic desensitization of the GABAA receptor in outside-out patches.
Article in Biophysical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Dynamics of receptor activation by agonists.Biophysical journal · 2024Review
- Electrophysiology of ionotropic GABA receptors.Cellular and molecular life sciences : CMLS · 2021Review
- Association of Model Neurotransmitters with Lipid Bilayer Membranes.Biophysical journal · 2020Article
- Article
- Exploring the mechanism of general anesthesia: kinetic analysis of GABAA receptor electrophysiology.Biophysical journal · 2015Article
- Expression of the γ2-subunit distinguishes synaptic and extrasynaptic GABA(A) receptors in NG2 cells of the hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Acute effects of ethanol on GABAOpen journal of neuroscience · 2013Article
- Neurosteroids and GABA-A Receptor Function.Frontiers in endocrinology · 2011Article
- Microscopic kinetic determinants of macroscopic currents: insights from coupling and uncoupling of GABAA receptor desensitization and deactivation.The Journal of physiology · 2007Article
- GABA affinity shapes IPSCs in thalamic nuclei.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Role of GABAergic inhibition in shaping odor-evoked spatiotemporal patterns in the Drosophila antennal lobe.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Neurosteroid administration and withdrawal alter GABAA receptor kinetics in CA1 hippocampus of female rats.The Journal of physiology · 2005Article
- An arginine involved in GABA binding and unbinding but not gating of the GABA(A) receptor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Ligand-gated ion channel currents in a nonstationary lyotropic model.Neurochemical research · 2003Review
- Coupled and uncoupled gating and desensitization effects by pore domain mutations in GABA(A) receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- Binding site stoichiometry and the effects of phosphorylation on human alpha1 homomeric glycine receptors.The Journal of physiology · 2002Article
- Slow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic function.The Journal of physiology · 2002Article
- Diminished allopregnanolone enhancement of GABA(A) receptor currents in a rat model of chronic temporal lobe epilepsy.The Journal of physiology · 2001Article
- Dominant gating governing transient GABA(A) receptor activity: a first latency and Po/o analysis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
- Structural determinants of fast desensitization and desensitization-deactivation coupling in GABAa receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2001Article
Corrections and comments
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2 authors.
Funding
Abstract
GABAA receptor function was studied in outside-out patches from guinea pig hippocampal neurons using a drug application system with an exchange time of under 1.5 ms. Application of GABA to these patches induced a Cl- conductance that desensitized with prolonged exposure. Increasing GABA concentrations induced larger conductance increases that were associated with more complex patterns of desensitization. Smaller GABA responses desensitized with monophasic kinetics, whereas large responses displayed bi- and triphasic kinetics. Desensitization of the response to 1 mM GABA was triphasic in about 70% of the patches (tau = 15.4, 207, and 1370 ms) and biphasic in about 30% of the patches (tau = 44 and 725 ms). All phases of desensitization reversed at the Cl- equilibrium potential. Over the concentration range from 3 microM to 3 mM, both the rate and the extent of desensitization increased; however, complete desensitization was rarely observed. The increase in desensitization rate was due to an increase in the relative contribution of the faster phases with increasing GABA. The time constants of the three phases were independent of concentration. The different phases are not mediated by separate receptor populations, because double pulse experiments demonstrated interconversion among the fastest phase and the two slower phases. We demonstrate the plausibility of a model in which multiphasic desensitization is a consequence of the faster association rate at higher GABA concentrations.
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