ArticleThe Biochemical journal1994
Okadaic acid treatment leads to a fragmentation of the trans-Golgi network and an increase in expression of TGN38 at the cell surface.
Article in The Biochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 68 citations in OpenAlex.
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- Endospanins regulate a postinternalization step of the leptin receptor endocytic pathway.The Journal of biological chemistry · 2011Article
- GMx33 associates with the trans-Golgi matrix in a dynamic manner and sorts within tubules exiting the Golgi.Molecular biology of the cell · 2006Article
- The role of mVps18p in clustering, fusion, and intracellular localization of late endocytic organelles.Molecular biology of the cell · 2003Article
- Localization of the PP2A B56gamma regulatory subunit at the Golgi complex: possible role in vesicle transport and migration.The American journal of pathology · 2003Article
- Rapsyn escorts the nicotinic acetylcholine receptor along the exocytic pathway via association with lipid rafts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
- The p55 tumour necrosis factor receptor TNFR1 contains a trans-Golgi network localization signal in the C-terminal region of its cytoplasmic tail.The Biochemical journal · 2002Article
- Biochemical characterization and subcellular localization of human copper transporter 1 (hCTR1).The Biochemical journal · 2002Article
- Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes.Molecular biology of the cell · 2002Article
- Endolyn is a mucin-like type I membrane protein targeted to lysosomes by its cytoplasmic tail.The Biochemical journal · 2000Article
- The organization of the Golgi complex and microtubules in skeletal muscle is fiber type-dependent.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Chitinase secretion by encysting Entamoeba invadens and transfected Entamoeba histolytica trophozoites: localization of secretory vesicles, endoplasmic reticulum, and Golgi apparatus.Infection and immunity · 1999Article
- Evidence for the participation of the neuron-specific CDK5 activator P35 during laminin-enhanced axonal growth.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Localization of a cyclopentenone prostaglandin to the endoplasmic reticulum and induction of BiP mRNA.The Biochemical journal · 1998Article
- Analysis of GLUT4 distribution in whole skeletal muscle fibers: identification of distinct storage compartments that are recruited by insulin and muscle contractions.The Journal of cell biology · 1998Article
- Regulation of endosome sorting by a specific PP2A isoform.The Journal of cell biology · 1998Article
- Efficient trafficking of TGN38 from the endosome to the trans-Golgi network requires a free hydroxyl group at position 331 in the cytosolic domain.Molecular biology of the cell · 1998Article
- Lumenal and transmembrane domains play a role in sorting type I membrane proteins on endocytic pathways.Molecular biology of the cell · 1998Article
- Okadaic acid induces selective arrest of protein transport in the rough endoplasmic reticulum and prevents export into COPII-coated structures.Molecular and cellular biology · 1998Article
- Phosphatidylinositol 3-kinase is required for the formation of constitutive transport vesicles from the TGN.The Journal of cell biology · 1997Article
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2 authors at 1 institution in 1 country.
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Abstract
Okadaic acid (OA) is a protein phosphatase inhibitor which has, among other properties, previously been shown to induce a fragmentation of the cisternae of the Golgi stack [for review, see Lucocq (1992) J. Cell Sci. 103, 875-880]. The effects of OA an reversible and mimic intracellular events which occur during mitosis. To date, due to a lack of endogenous marker proteins, the effects of OA on the trans-Golgi network (TGN) has not been studied. Certain drugs, e.g. Brefeldin A (BFA), have different effects on the morphology of the Golgi stack and the TGN; it is therefore relevant to ask what effect(s) OA has on the TGN. We now present data from a study in which we have used antibodies to TGN38, an integral membrane protein predominantly localized to the TGN of rat NRK cells [Luzio, Brake, Banting, Howell, Braghetta and Stanley (1990) Biochem. J. 270, 97-102], to investigate the effects of OA on this organelle. OA induces a reversible fragmentation of the TGN. This fragmentation occurs with similar kinetics to that observed within the Golgi stack, and is independent of protein synthesis. The sensitivity of the TGN to OA is similar to that of the Golgi stack. The fragmentation of the TGN induced by OA also leads to a 10-fold increase in the level of TGN38 expressed at the plasma membrane.
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