ArticleThe Biochemical journal1994
Regulation of expression of the human fructose transporter (GLUT5) by cyclic AMP.
Article in The Biochemical journal, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 54 citations in OpenAlex.
- A Comparative Analysis of Orexins in the Physio-Pathological Processes of the Male Genital Tract: New Challenges? A Review.Veterinary sciences · 2024Review
- Review
- S100P contributes to promoter demethylation and transcriptional activation of SLC2A5 to promote metastasis in colorectal cancer.British journal of cancer · 2021Article
- Glucose transporters in the small intestine in health and disease.Pflugers Archiv : European journal of physiology · 2020Review
- Ligand Screening Systems for Human Glucose Transporters as Tools in Drug Discovery.Frontiers in chemistry · 2018Review
- The Sweet Path to Metabolic Demise: Fructose and Lipid Synthesis.Trends in endocrinology and metabolism: TEM · 2016Review
- Pathogenesis of human enterovirulent bacteria: lessons from cultured, fully differentiated human colon cancer cell lines.Microbiology and molecular biology reviews : MMBR · 2013Review
- Regulation of the fructose transporter GLUT5 in health and disease.American journal of physiology. Endocrinology and metabolism · 2008Review
- Intestinal sugar transport.World journal of gastroenterology · 2006Review
- Fructose modulates GLUT5 mRNA stability in differentiated Caco-2 cells: role of cAMP-signalling pathway and PABP (polyadenylated-binding protein)-interacting protein (Paip) 2.The Biochemical journal · 2003Article
- Dietary and developmental regulation of intestinal sugar transport.The Biochemical journal · 2001Review
- Glucose and thyroid hormone co-regulate the expression of the intestinal fructose transporter GLUT5.The Biochemical journal · 1999Article
- Expression of the fructose transporter GLUT5 in human breast cancer.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Sugar-dependent expression of the fructose transporter GLUT5 in Caco-2 cells.The Biochemical journal · 1995Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
The effect of cyclic AMP on the expression of the fructose transporter, GLUT5, was studied in Caco-2 cells, a human colon cancer cell line that differentiates spontaneously in culture into cells with the properties of small intestine enterocytes. Treatment of differentiated Caco-2 cells with 50 microM forskolin, which stimulates adenylate cyclase and raises intracellular cyclic AMP levels, increased fructose uptake 2-fold and raised GLUT5 protein and mRNA levels 5- and 7-fold respectively. The increased GLUT5 mRNA levels in forskolin-treated cells are a result of stabilization of GLUT5 mRNA in these cells and increased transcription. The effect of cyclic AMP on GLUT5 transcription was assessed by measuring the activity of human GLUT5 promoter-reporter gene constructs in forskolin-treated differentiated Caco-2 cells. The results showed that forskolin stimulated the activity of the GLUT5-reporter gene constructs and this stimulatory effect was mediated by cis-acting regulatory sequences.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.