ArticleAnnals of the rheumatic diseases1994
The gut as an inductive site for synovial and extra-articular immune responses in rheumatoid arthritis.
Article in Annals of the rheumatic diseases, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 26 citations in OpenAlex.
- Review
- Oral tolerance as antigen-specific immunotherapy.Immunotherapy advances · 2021Review
- Vaccination response to protein and carbohydrate antigens in patients with rheumatoid arthritis after rituximab treatment.Arthritis research & therapy · 2010Article
- Rheumatoid factor isotype switch and somatic mutation variants within rheumatoid arthritis synovium.Immunology · 1999Article
- Evidence for differential effects of sulphasalazine on systemic and mucosal immunity in rheumatoid arthritis.Annals of the rheumatic diseases · 1995Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo analyse the immunological interactions between the gut lymphoid tissue, synovium, and peripheral blood compartments in patients with rheumatoid arthritis (RA) and ankylosing spondylitis (AS).
methodsPatients with RA and AS and healthy controls were orally or parenterally immunised with an influenza virus vaccine. Antigen-specific antibody responses were measured at the single cell level by ELISPOT assay using lymphocytes isolated from peripheral blood and from enzymatically dispersed synovial tissues.
resultsBoth oral and parenteral immunisations induced antigen-specific antibody-secreting cells in the synovial tissue of patients with RA. Parenterally immunised patients with RA showed significantly decreased antigen-specific antibody responses in peripheral blood compared with patients with AS and with healthy controls. In contrast, oral vaccination evoked comparable peripheral blood antibody responses in all three study groups.
conclusionsDespite a decreased immune responsiveness in the systemic compartment, the functional status of the gut-associated lymphoid tissue in patients with RA is intact. In addition, there is evidence that the lymphocytes in the inflamed joints are accessible for signals both from the systemic and mucosal compartments. The findings of immunological 'cross-talk' are relevant to future vaccination and tolerization procedures in patients with RA.
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