ArticleAmerican journal of human genetics1994
Comparison of statistics for candidate-gene association studies using cases and parents.
Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.PLoS genetics · 2011Pooled it
- Allelic heterogeneity in genetic association meta-analysis: an application to DTNBP1 and schizophrenia.Human heredity · 2010Pooled it
- The oligogenic inheritance test GCOD detects risk genes and their interactions in congenital heart defects.Genome research · 2026Article
- Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family-based hybrid designs.Genetic epidemiology · 2021Article
- Case-Parent Trio Studies in Cleft Lip and Palate.Global medical genetics · 2020Review
- Allowing for population stratification in case-only studies of gene-environment interaction, using genomic control.Human genetics · 2015Article
- Learning about the X from our parents.Frontiers in genetics · 2015Article
- Analytic power and sample size calculation for the genotypic transmission/disequilibrium test in case-parent trio studies.Biometrical journal. Biometrische Zeitschrift · 2014Article
- Empirical pathway analysis, without permutation.Biostatistics (Oxford, England) · 2013Article
- Analytical methods for disease association studies with immunogenetic data.Methods in molecular biology (Clifton, N.J.) · 2012Article
- Using ancestry matching to combine family-based and unrelated samples for genome-wide association studies.Statistics in medicine · 2010Article
- Evaluating diagnostic accuracy of genetic profiles in affected offspring families.Statistics in medicine · 2010Article
- Joint genetic susceptibility to type 1 diabetes and autoimmune thyroiditis: from epidemiology to mechanisms.Endocrine reviews · 2008Review
- Review and evaluation of methods correcting for population stratification with a focus on underlying statistical principles.Human heredity · 2008Review
- Impact of non-ignorable missingness on genetic tests of linkage and/or association using case-parent trios.BMC genetics · 2005Article
- Genetic association analysis using data from triads and unrelated subjects.American journal of human genetics · 2005Article
- Detecting non-multiplicative genotype relative risks from transmissions of parental alleles to affected children.Journal of human genetics · 2005Article
- Melanocortin-4 receptor gene variant I103 is negatively associated with obesity.American journal of human genetics · 2004Article
- Dopamine D4 receptor and tyrosine hydroxylase genes in bipolar disorder: evidence for a role of DRD4.Molecular psychiatry · 2002Article
- Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects.American journal of human genetics · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Studies of association between candidate genes and disease can be designed to use cases with disease, and in place of nonrelated controls, their parents. The advantage of this design is the elimination of spurious differences due to ethnic differences between cases and nonrelated controls. However, several statistical methods of analysis have been proposed in the literature, and the choice of analysis is not always clear. We review some of the statistical methods currently developed and present two new statistical methods aimed at specific genetic hypotheses of dominance and recessivity of the candidate gene. These new methods can be more powerful than other current methods, as demonstrated by simulations. The basis of these new statistical methods is a likelihood approach. The advantage of the likelihood framework is that regression models can be developed to assess genotype-environment interactions, as well as the relative contribution that alleles at the candidate-gene locus make to the relative risk (RR) of disease. This latter development allows testing of (1) whether interactions between alleles exist, on the scale of log RR, and (2) whether alleles originating from the mother or father of a case impart different risks, i.e., genomic imprinting.
Indexed as
Identifiers
8037216PMC1918347W1733541714What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.