ArticleAmerican journal of human genetics1994
Recurrent 1;17 translocations in human neuroblastoma reveal nonhomologous mitotic recombination during the S/G2 phase as a novel mechanism for loss of heterozygosity.
Article in American journal of human genetics, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 61 citations in OpenAlex.
- Molecular pathogenesis of peripheral neuroblastic tumors.Oncogene · 2010Review
- The emerging molecular pathogenesis of neuroblastoma: implications for improved risk assessment and targeted therapy.Genome medicine · 2009Article
- Molecular biology of neuroblastoma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2007Review
- Article
- [Neuroblastoma].Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2005Review
- Neuroblastoma tumour genetics: clinical and biological aspects.Journal of clinical pathology · 2001Review
- Gain of chromosome arm 17q is associated with unfavourable prognosis in neuroblastoma, but does not involve mutations in the somatostatin receptor 2(SSTR2) gene at 17q24.British journal of cancer · 1999Article
- Escape from het-6 incompatibility in Neurospora crassa partial diploids involves preferential deletion within the ectopic segment.Genetics · 1996Article
- Allelic loss of the short arm of chromosome 4 in neuroblastoma suggests a novel tumour suppressor gene locus.Human genetics · 1996Article
- No mutations found by RET mutation scanning in sporadic and hereditary neuroblastoma.Human genetics · 1996Article
- A region of consistent deletion in neuroblastoma maps within human chromosome 1p36.2-36.3.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
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9 authors at 1 institution in 1 country.
Funding
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Abstract
Neuroblastomas often show loss of heterozygosity of the chromosomal region 1p36 (LOH 1p), probably reflecting loss of a tumor-suppressor gene. Here we describe three neuroblastoma tumors and two cell lines in which LOH 1p results from an unbalanced translocation between the p arm of chromosome 1 and the q arm of chromosome 17. Southern blot and cytogenetic analyses show that in all cases the chromosome 17 homologue from which the 1;17 translocation was derived is still present and intact. This suggests a model in which a translocation between the short arm of chromosome 1 and the long arm of chromosome 17 takes place in the S/G2 phase of the cell cycle and results in LOH 1p. Nonhomologous mitotic recombination in the S/G2 phase is a novel mechanism of LOH.
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Identifiers
8037211PMC1918374W1572940497What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.