ArticleNucleic acids research1994
c-Myc binds to 5' flanking sequence motifs of the dihydrofolate reductase gene in cellular extracts: role in proliferation.
Article in Nucleic acids research, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
15 citing papers in PubMed.
- LncEGFL7OS regulates human angiogenesis by interacting with MAX at the EGFL7/miR-126 locus.eLife · 2019Article
- The Nutrient-Sensing Hexosamine Biosynthetic Pathway as the Hub of Cancer Metabolic Rewiring.Cells · 2018Review
- Gamabufotalin triggers c-Myc degradation via induction of WWP2 in multiple myeloma cells.Oncotarget · 2016Article
- Transcriptional Regulation of CRD-BP by c-myc: Implications for c-myc Functions.Genes & cancer · 2010Article
- c-Myc represses the proximal promoters of GADD45a and GADD153 by a post-RNA polymerase II recruitment mechanism.Oncogene · 2004Article
- Article
- Translocations involving c-myc and c-myc function.Oncogene · 2001Review
- The transcriptional program of a human B cell line in response to Myc.Nucleic acids research · 2001Article
- Chromosomal and extrachromosomal instability of the cyclin D2 gene is induced by Myc overexpression.Neoplasia (New York, N.Y.) · 1999Article
- c-Myc target genes involved in cell growth, apoptosis, and metabolism.Molecular and cellular biology · 1999Review
- c-Myc target gene specificity is determined by a post-DNAbinding mechanism.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- Identification of putative c-Myc-responsive genes: characterization of rcl, a novel growth-related gene.Molecular and cellular biology · 1997Article
- YY1 and c-Myc associate in vivo in a manner that depends on c-Myc levels.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Genomic instability in MycER-activated Rat1A-MycER cells.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1996Article
- The c-myc protein represses the lambda 5 and TdT initiators.Nucleic acids research · 1995Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The dihydrofolate reductase is a key enzyme of the folate metabolism which supplies the cell with dTTPs for DNA synthesis. Using cellular extracts, we demonstrate the formation of c-Myc/Max heterodimers at the dihydrofolate reductase (DHFR) 5' flanking CANNTG (E-box) motifs. The presence of these complexes correlates with c-Myc levels and active cellular proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.