ArticleMolecular and cellular biology1994
Evidence for a critical role for the cytoplasmic region of the interleukin 2 (IL-2) receptor gamma chain in IL-2, IL-4, and IL-7 signalling.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 62 citations in OpenAlex.
- Novel WT1 Target Genes:BioMed research international · 2020Article
- TGF-β-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Ectodomain shedding of interleukin-2 receptor beta and generation of an intracellular functional fragment.The Journal of biological chemistry · 2010Article
- A critical role for cyclin C in promotion of the hematopoietic cell cycle by cooperation with c-Myc.Molecular and cellular biology · 1998Article
- Pyk2 is a downstream mediator of the IL-2 receptor-coupled Jak signaling pathway.Genes & development · 1998Article
- Shared gamma(c) subunit within the human interleukin-7 receptor complex. A molecular basis for the pathogenesis of X-linked severe combined immunodeficiency.The Journal of clinical investigation · 1997Article
- Identification of a novel receptor/signal transduction pathway for IL-15/T in mast cells.The EMBO journal · 1996Article
- Interleukin-4-specific signal transduction events are driven by homotypic interactions of the interleukin-4 receptor alpha subunit.The EMBO journal · 1996Article
- Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- ErbB-2 is a common auxiliary subunit of NDF and EGF receptors: implications for breast cancer.The EMBO journal · 1996Article
- Molecular mechanisms regulating the hyaluronan binding activity of the adhesion protein CD44.Journal of neuro-oncology · 1995Article
- Critical role of the interleukin 2 (IL-2) receptor gamma-chain-associated Jak3 in the IL-2-induced c-fos and c-myc, but not bcl-2, gene induction.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
- Activation of Stat5 by interleukin 2 requires a carboxyl-terminal region of the interleukin 2 receptor beta chain but is not essential for the proliferative signal transmission.Proceedings of the National Academy of Sciences of the United States of America · 1995Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The high-affinity interleukin 2 receptor (IL-2R) consists of at least three distinct subunits: the IL-2R alpha chain (IL-2R alpha), beta chain (IL-2R beta), and gamma chain (IL-2R gamma). It has been shown that the cytoplasmic region of IL-2R beta, but not of IL-2R alpha, is essential for IL-2 signalling to the cell interior. In the present study, we examined the functional role of the IL-2R gamma cytoplasmic region in the IL-3-dependent mouse hematopoietic cell line BAF-B03, which expresses the endogenous IL-2R alpha and IL-2R gamma, or its subline F7, which additionally expresses human IL-2R beta cDNA. We show that overexpression of a mutant IL-2R gamma, lacking all but 7 amino acids of its cytoplasmic region, results in the selective inhibition of IL-2-induced c-fos gene activation and cellular proliferation in F7 cells. When two chimeric receptor molecules in which the cytoplasmic regions of IL-2R beta and IL-2R gamma had been swapped with each other (IL-2R beta/gamma and IL-2R gamma/beta) were coexpressed in BAF-B03, the cells responded to IL-2. These results indicate the critical importance of the IL-2-induced functional cooperation of the two cytoplasmic regions. Finally, we provide evidence that the IL-2R gamma cytoplasmic region is also critical for the IL-4 and IL-7-induced growth signal transduction in BAF-B03.
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