ArticleMolecular and cellular biology1994
The immediate-early gene Egr-1 regulates the activity of the thymidine kinase promoter at the G0-to-G1 transition of the cell cycle.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 92 citations in OpenAlex.
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- Endothelial cell cycle state determines propensity for arterial-venous fate.Nature communications · 2022Article
- Glial Cell AMPA Receptors in Nervous System Health, Injury and Disease.International journal of molecular sciences · 2019Review
- Molecular targets and signaling pathways regulated by nuclear translocation of syndecan-1.BMC cell biology · 2017Article
- The serine protease inhibitor elafin maintains normal growth control by opposing the mitogenic effects of neutrophil elastase.Oncogene · 2015Article
- P2Y2 purinergic receptor activation is essential for efficient hepatocyte proliferation in response to partial hepatectomy.American journal of physiology. Gastrointestinal and liver physiology · 2014Article
- MicroRNA-gene association as a prognostic biomarker in cancer exposes disease mechanisms.PLoS computational biology · 2013Article
- Article
- HGF-promoted motility in primary human melanocytes depends on CD44v6 regulated via NF-kappa B, Egr-1, and C/EBP-beta.The Journal of investigative dermatology · 2010Article
- Early biomarkers and potential mediators of ventilation-induced lung injury in very preterm lambs.Respiratory research · 2009Article
- hEGR1 is induced by EGF, inhibited by gefitinib in bladder cell lines and related to EGF receptor levels in bladder tumours.British journal of cancer · 2007Article
- Chlamydia pneumoniae infection promotes a proliferative phenotype in the vasculature through Egr-1 activation in vitro and in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Extracellular ATP stimulates the early growth response protein 1 (Egr-1) via a protein kinase C-dependent pathway in the human osteoblastic HOBIT cell line.The Biochemical journal · 2003Article
- The transcription factor early growth response factor-1 (EGR-1) promotes apoptosis of neuroblastoma cells.The Biochemical journal · 2003Article
- Inhibition of Egr-1 expression reverses transformation of prostate cancer cells in vitro and in vivo.Oncogene · 2003Article
- High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis.The Journal of clinical investigation · 2000Article
- Analysis of prolactin-modulated gene expression profiles during the Nb2 cell cycle using differential screening techniques.Genome biology · 2000Article
- Human thymidine kinase can functionally replace herpes simplex virus type 1 thymidine kinase for viral replication in mouse sensory ganglia and reactivation from latency upon explant.Journal of virology · 1998Article
- Cyclosporin A-sensitive transcription factor Egr-3 regulates Fas ligand expression.Molecular and cellular biology · 1998Article
- [Egr-1 transcription factor regulates the growth of glomerular mesangium cells].Medizinische Klinik (Munich, Germany : 1983) · 1997Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Production of thymidine kinase (TK) protein parallels the onset of DNA synthesis during the cell cycle. This process is regulated at transcriptional, posttranscriptional, and translational levels to cause a 40- to 50-fold increase in cytosolic enzymatic activity as cells progress from G1 to S phase. Transcriptional activation of the mouse TK gene through the cell cycle is dependent upon previously characterized cis elements of the proximal promoter, called MT1, MT2, and MT3, that bind at least two different complexes: TKE during the transition of cells from quiescence (G0) to G1, and Yi later at the G1/S boundary. To identify the transcription factors involved in this regulation, we screened a mouse fibroblast cDNA expression library with a labeled MT3 oligonucleotide probe and isolated a clone that encodes Egr-1, an immediate-early transcription factor, whose expression is regulated by serum or growth factors during the G0-to-G1 transition when cells reenter the cell cycle. Electrophoretic mobility shift assays demonstrate that Egr-1 is involved in the TKE complex that binds to the MT3 element and that expression of Egr-1 induces transcription of a mouse TK-chloramphenicol acetyltransferase reporter in transient transfections. These results suggest a role for Egr-1 in regulating expression of the TK gene at the G0-to-G1 transition.
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