ArticleMolecular and cellular biology1994
Chromatin structure modulation in Saccharomyces cerevisiae by centromere and promoter factor 1.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Transcription factor CBF-1 is critical for circadian gene expression by modulating WHITE COLLAR complex recruitment to the frq locus.PLoS genetics · 2018Article
- Transcription mediated insulation and interference direct gene cluster expression switches.eLife · 2014Article
- The INO80 chromatin remodeling complex prevents polyploidy and maintains normal chromatin structure at centromeres.Genes & development · 2012Article
- Endogenous transcription at the centromere facilitates centromere activity in budding yeast.Current biology : CB · 2011Article
- Integrated approaches reveal determinants of genome-wide binding and function of the transcription factor Pho4.Molecular cell · 2011Article
- Dissection of combinatorial control by the Met4 transcriptional complex.Molecular biology of the cell · 2010Article
- A translational signature for nucleosome positioning in vivo.Nucleic acids research · 2009Article
- A genomic code for nucleosome positioning.Nature · 2006Article
- Cbf1p modulates chromatin structure, transcription and repair at the Saccharomyces cerevisiae MET16 locus.Nucleic acids research · 2004Article
- In vivo chromatin remodeling by yeast ISWI homologs Isw1p and Isw2p.Genes & development · 2001Article
- Article
- The N terminus of the centromere H3-like protein Cse4p performs an essential function distinct from that of the histone fold domain.Molecular and cellular biology · 2000Article
- Preferential accessibility of the yeast his3 promoter is determined by a general property of the DNA sequence, not by specific elements.Molecular and cellular biology · 2000Article
- SURVEY AND SUMMARY: Saccharomyces cerevisiae basic helix-loop-helix proteins regulate diverse biological processes.Nucleic acids research · 2000Review
- Metabolism of sulfur amino acids in Saccharomyces cerevisiae.Microbiology and molecular biology reviews : MMBR · 1997Review
- A heteromeric complex containing the centromere binding factor 1 and two basic leucine zipper factors, Met4 and Met28, mediates the transcription activation of yeast sulfur metabolism.The EMBO journal · 1996Article
- The multifunctional transcription factors Abf1p, Rap1p and Reb1p are required for full transcriptional activation of the chromosomal PGK gene in Saccharomyces cerevisiae.Molecular & general genetics : MGG · 1996Article
- Chromatin structure snap-shots: rapid nuclease digestion of chromatin in yeast.Nucleic acids research · 1995Article
- The nucleotide mapping of DNA double-strand breaks at the CYS3 initiation site of meiotic recombination in Saccharomyces cerevisiae.The EMBO journal · 1995Article
- Evidence that the MIF2 gene of Saccharomyces cerevisiae encodes a centromere protein with homology to the mammalian centromere protein CENP-C.Molecular biology of the cell · 1995Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
CPF1 is an abundant basic-helix-loop-helix-ZIP protein that binds to the CDEI motif in Saccharomyces cerevisiae centromeres and in the promoters of numerous genes, including those encoding enzymes of the methionine biosynthetic pathway. Strains lacking CPF1 are methionine auxotrophs, and it has been proposed that CPF1 might positively influence transcription at the MET25 and MET16 genes by modulating promoter chromatin structure. We test this hypothesis and show that the regions surrounding the CDEI motifs in the MET25 and MET16 promoters are maintained in a nucleosome-free state and that this requires the entire CPF1 protein. However, the chromatin structure around the CDEI motifs does not change on derepression of transcription and does not correlate with the methionine phenotype of the cell. An intact CDEI motif but not CPF1 is required for transcriptional activation from a region of the MET25 upstream activation sequence. Our results suggest that CPF1 functions to modulate chromatin structure around the CDEI motif but that these changes at the MET25 and MET16 promoters do not explain how CPF1 functions to maintain methionine-independent growth. The presence of CPF1-dependent chromatin structures at these promoters leads to a weak repression of transcription.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.