ArticleMolecular and cellular biology1994
Involvement of the transcription factor PU.1/Spi-1 in myeloid cell-restricted expression of an interferon-inducible gene encoding the human high-affinity Fc gamma receptor.
Article in Molecular and cellular biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 88 citations in OpenAlex.
- The ETS-family transcription factor PU.1 is a critical regulator of the inhibitory Fcγ receptor IIB expression in humans.Journal of immunology (Baltimore, Md. : 1950) · 2025Article
- Identification and characterization of a PU.1/Spi-B binding site in the bovine leukemia virus long terminal repeat.Oncogene · 2003Article
- TIF1beta functions as a coactivator for C/EBPbeta and is required for induced differentiation in the myelomonocytic cell line U937.Genes & development · 2001Article
- Ets target genes: past, present and future.Oncogene · 2000Review
- Article
- PU.1 regulates both cytokine-dependent proliferation and differentiation of granulocyte/macrophage progenitors.The EMBO journal · 1998Article
- Defective B cell receptor-mediated responses in mice lacking the Ets protein, Spi-B.The EMBO journal · 1997Article
- Specific DNA binding of Stat5, but not of glucocorticoid receptor, is required for their functional cooperation in the regulation of gene transcription.Molecular and cellular biology · 1997Article
- Combinatorial determinants of tissue-specific transcription in B cells and macrophages.Molecular and cellular biology · 1997Article
- The Ets protein Spi-B is expressed exclusively in B cells and T cells during development.The Journal of experimental medicine · 1996Article
- Sp1 binds two sites in the CD11c promoter in vivo specifically in myeloid cells and cooperates with AP1 to activate transcription.Molecular and cellular biology · 1996Article
- Spi-1/PU.1 transgenic mice develop multistep erythroleukemias.Molecular and cellular biology · 1996Article
- Expression of the human acute myeloid leukemia gene AML1 is regulated by two promoter regions.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- PU.1 (Spi-1) and C/EBP alpha regulate expression of the granulocyte-macrophage colony-stimulating factor receptor alpha gene.Molecular and cellular biology · 1995Article
- Signal transduction and activation of gene transcription by interferons.Gene expression · 1995Review
- The Spi-1/PU.1 and Spi-B ets family transcription factors and the recombination signal binding protein RBP-J kappa interact with an Epstein-Barr virus nuclear antigen 2 responsive cis-element.The EMBO journal · 1994Article
- PU.1 and partners: regulation of haematopoietic stem cell fate in normal and malignant haematopoiesis.Journal of cellular and molecular medicineReview
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Induction by gamma interferon (IFN-gamma) of the gene encoding the human high-affinity Fc gamma receptor (Fc gamma R1) in myeloid cells requires an IFN-gamma response region (GRR) and a myeloid cell-activating transcription element (MATE). GRR and MATE interact with factors to form, respectively, an IFN-gamma-activating complex (GIRE-BP), depending on the phosphorylation of the 91-kDa protein (subunit of ISGF3), and a cell-type-specific complex (MATE-BP). Although GIRE-BP is detected in cells of different origins after IFN-gamma treatment, the presence of MATE-BP was found to be restricted to B- and myeloid cell lines. Sequence analysis of a cDNA encoding a polypeptide recognizing specifically the MATE motif led to the identification of this product as the proto-oncogene PU.1/Spi-1, a transcriptional activator expressed in myeloid and B cells. Expression of this factor in nonhematopoietic cells allowed IFN-gamma-induced expression of a reporter gene under control of the GRR and MATE sequences. The presence of these motifs in other gene promoters indicates that the binding of PU.1/Spi-1 and IFN regulatory proteins to their respective motifs could be part of a general mechanism leading to cell-type-restricted and IFN-induced gene expression.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.