ArticleJournal of virology1994
Functional and biological properties of an avian variant long terminal repeat containing multiple A to G conversions in the U3 sequence.
Article in Journal of virology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- ADAR Editing in Viruses: An Evolutionary Force to Reckon with.Genome biology and evolution · 2021Review
- Adenosine Deaminases Acting on RNA (ADARs) and Viral Infections.Annual review of virology · 2021Article
- Epitranscriptomic marks: Emerging modulators of RNA virus gene expression.Wiley interdisciplinary reviews. RNA · 2020Review
- Complete genome sequencing and characterization revealed a recombinant subgroup B isolate of avian leukosis virus with a subgroup J-like U3 region.Virus genes · 2017Article
- Hyperediting of human T-cell leukemia virus type 2 and simian T-cell leukemia virus type 3 by the dsRNA adenosine deaminase ADAR-1.The Journal of general virology · 2012Article
- ADARs: viruses and innate immunity.Current topics in microbiology and immunology · 2012Review
- Enhancement of replication of RNA viruses by ADAR1 via RNA editing and inhibition of RNA-activated protein kinase.Journal of virology · 2011Review
- Review
- Inosine-containing RNA is a novel innate immune recognition element and reduces RSV infection.PloS one · 2011Article
- Nature, position, and frequency of mutations made in a single cycle of HIV-1 replication.Journal of virology · 2010Article
- Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae).BMC genetics · 2009Article
- A new retroelement constituted by a natural alternatively spliced RNA of murine replication-competent retroviruses.The EMBO journal · 2003Article
- RNA editing by adenosine deaminases that act on RNA.Annual review of biochemistry · 2002Review
- Article
- Specific cleavage of hyper-edited dsRNAs.The EMBO journal · 2001Article
- Kinetics of formation of hypoxanthine containing base pairs by HIV-RT: RNA template effects on the base substitution frequencies.Nucleic acids research · 2001Article
- Antisense RNA: function and fate of duplex RNA in cells of higher eukaryotes.Microbiology and molecular biology reviews : MMBR · 1998Review
- Retroviral mutation rates and A-to-G hypermutations during different stages of retroviral replication.Journal of virology · 1996Article
- Retroviral insertional activation of the c-myb proto-oncogene in a Marek's disease T-lymphoma cell line.Journal of virology · 1996Article
- The noncoding and surface envelope coding sequences of myeloblastosis-associated virus are respectively responsible for nephroblastoma development and renal hyperplasia.Journal of virology · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We previously reported that infection of chicken embryonic neuroretina cells with Rous-associated virus type 1 leads to the frequent occurrence of spliced readthrough transcripts containing viral and cellular sequences. Generation of such chimeric transcripts constitutes a very early step in oncogene transduction. We report, here, the isolation of a c-mil transducing retrovirus, designated IC4, which contains a highly mutated U3 sequence in which 48% of A is converted to G. Functional analysis of this variant U3 indicated that these mutations do not impair viral transcription and replication; however, they abolish functioning of its polyadenylation signal, thus allowing readthrough transcription of downstream cellular sequences. On the basis of these results, we designed a nonreplicative retroviral vector, pIC4Neo, expressing the neomycin resistance (Neo(r)) gene under the control of the IC4 long terminal repeat. Infection of nondividing neuroretina cells with virus produced by a packaging cell line transfected with pIC4Neo occasionally resulted in sustained cell proliferation. Two independent G418-resistant proliferating cultures were found to express hybrid RNAs containing viral and cellular sequences. These sequences were characterized by reverse transcription-PCR and were identified in both cultures, suggesting that proliferation was correlated with a common integration locus. These results indicate that IC4Neo virus functions as a useful insertional mutagen and may allow identification of genes potentially involved in regulation of cell division.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.