ArticleThe Journal of cell biology1994
The bovine desmocollin family: a new gene and expression patterns reflecting epithelial cell proliferation and differentiation.
Article in The Journal of cell biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 75 citations in OpenAlex.
- The role of the desmosomal protein desmocollin 2 in tumour progression in triple negative breast cancer patients.Cancer cell international · 2023Article
- A Genetic Investigation of Island Jersey Cattle, the Foundation of the Jersey Breed: Comparing Population Structure and Selection to Guernsey, Holstein, and United States Jersey Cattle.Frontiers in genetics · 2020Article
- Article
- The biology of the desmosome-like junction a versatile anchoring junction and signal transducer in the seminiferous epithelium.International review of cell and molecular biology · 2011Review
- Discovering the molecular components of intercellular junctions--a historical view.Cold Spring Harbor perspectives in biology · 2009Review
- Protein kinase C isoenzymes differentially regulate the differentiation-dependent expression of adhesion molecules in human epidermal keratinocytes.Experimental dermatology · 2009Article
- Suprabasal desmoglein 3 expression in the epidermis of transgenic mice results in hyperproliferation and abnormal differentiation.Molecular and cellular biology · 2002Article
- Molecular interactions between desmosomal cadherins.The Biochemical journal · 2002Article
- Mice lacking desmocollin 1 show epidermal fragility accompanied by barrier defects and abnormal differentiation.The Journal of cell biology · 2001Article
- Plakophilins 2a and 2b: constitutive proteins of dual location in the karyoplasm and the desmosomal plaque.The Journal of cell biology · 1996Article
- Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart.The Journal of cell biology · 1996Article
- Distinct desmocollin isoforms occur in the same desmosomes and show reciprocally graded distributions in bovine nasal epidermis.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- IgA antikeratinocyte surface autoantibodies from two types of intercellular IgA vesiculopustular dermatosis recognize distinct isoforms of desmocollin.Archives of dermatological research · 1996Article
- Immunohistochemical staining of desmosomal components in oral squamous cell carcinomas and its association with tumour behaviour.British journal of cancer · 1996Article
- Bovine desmocollin genes (DSC1, DSC2, DSC3) cluster on chromosome 24q21/q22.Mammalian genome : official journal of the International Mammalian Genome Society · 1995Article
- Epithelial development and differentiation: the role of desmosomes. The Watson Smith Lecture 1996.Journal of the Royal College of Physicians of LondonReview
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have discovered a third bovine desmocollin gene, DSC3, and studied expression of all three desmocollin genes, DSC1, 2, and 3, by Northern blotting, RT-PCR and in situ hybridization. DSC1 is strongly expressed in epidermis and tongue papillae, showing a "skin"-type pattern resembling that previously described for keratins 1 and 10. Expression is absent from the epidermal basal layer but appears in the immediate suprabasal layers and continues uniformly to the lower granular layer. In tongue epithelium, expression is suprabasal and strictly localized to papillae, being absent from interpapillary regions. In other epithelial low level DSC1 expression is detectable only by RT-PCR. The distribution of Dsc1 glycoproteins, detected by an isoform-specific monoclonal antibody, closely reflects mRNA distribution in epidermis and tongue. DSC2 is ubiquitously expressed in epithelia and cardiac muscle. In stratified epithelia, expression appears immediately suprabasal, continuing weakly to the lower granular layer in epidermis and to just above half epithelial thickness in interpapillary tongue, oesophageal, and rumenal epithelia. DSC3 expression is restricted to the basal and immediately suprabasal layers in stratified epithelia. In deep rete ridges DSC expression strikingly resembles the distribution of stem, transit-amplifying, and terminally differentiating cells described by others. DSC3 expression is strongly basal, DSC2 is strong in 5-10 suprabasal layers, and then weakens to be superseded by strong DSC1. These results suggest that desmocollin isoform expression has important functional consequences in epithelial proliferation, stratification, and differentiation. The data also provide a standard for nomenclature of the desmocollins.
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