ArticleClinical and experimental immunology1994
Binding of pentraxins to different nuclear structures: C-reactive protein binds to small nuclear ribonucleoprotein particles, serum amyloid P component binds to chromatin and nucleoli.
Article in Clinical and experimental immunology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 103 citations in OpenAlex.
- Predictive Value of C-Reactive Protein Levels in Adults with Major Burns in Benin City, Nigeria.Annals of burns and fire disasters · 2026Article
- Effectiveness of functional ingredients to enhance gill disease in Atlantic salmon (Salmo salar, L.).PloS one · 2024Article
- Analysis of Clinical Symptoms and Biochemical Parameters in Odontogenic Cellulitis of the Head and Neck Region in Children.Children (Basel, Switzerland) · 2023Article
- Dementia in the older population is associated with neocortex content of serum amyloid P component.Brain communications · 2021Article
- Therapeutic Lowering of C-Reactive Protein.Frontiers in immunology · 2020Review
- IgG and Fcγ Receptors in Intestinal Immunity and Inflammation.Frontiers in immunology · 2019Review
- The Pentraxins 1975-2018: Serendipity, Diagnostics and Drugs.Frontiers in immunology · 2018Review
- Serum Amyloid P Component and Systemic Fungal Infection: Does It Protect the Host or Is It a Trojan Horse?Open forum infectious diseases · 2016Article
- Pharmacological removal of serum amyloid P component from intracerebral plaques and cerebrovascular Aβ amyloid deposits in vivo.Open biology · 2016Article
- Pentraxins and Fc receptors.Immunological reviews · 2012Review
- Identification of calcium-binding proteins associated with the human sperm plasma membrane.Reproductive biology and endocrinology : RB&E · 2010Article
- Lack of effect of a single injection of human C-reactive protein on murine lupus or nephrotoxic nephritis.Arthritis and rheumatism · 2010Article
- Pentraxins in innate immunity: from C-reactive protein to the long pentraxin PTX3.Journal of clinical immunology · 2008Review
- Serum amyloid P aids complement-mediated immunity to Streptococcus pneumoniae.PLoS pathogens · 2007Article
- C-reactive protein levels in subjects with Prader-Willi syndrome and obesity.Genetics in medicine : official journal of the American College of Medical Genetics · 2006Article
- Protective molecules--C-reactive protein (CRP), serum amyloid P (SAP), pentraxin3 (PTX3), mannose-binding lectin (MBL), and apolipoprotein A1 (Apo A1), and their autoantibodies: prevalence and clinical significance in autoimmunity.Journal of clinical immunology · 2005Review
- Serum amyloid P component levels are not decreased in patients with systemic lupus erythematosus and do not rise during an acute phase reaction.Annals of the rheumatic diseases · 2004Article
- Autoimmunity and glomerulonephritis in mice with targeted deletion of the serum amyloid P component gene: SAP deficiency or strain combination?Immunology · 2004Article
- Autoantibodies and thrombophilia in RA: TNFalpha and TNFalpha blockers.Annals of the rheumatic diseases · 2004Article
- C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity.Immunologic research · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
Binding of the human pentraxin plasma proteins, C-reactive protein (CRP) and serum amyloid P component (SAP), to the nuclei of human cells was studied using whole acute phase serum as the source of the proteins and confocal immunofluorescence microscopy. CRP and SAP clearly bound to distinct, different structures. Double staining with MoAbs to the Sm D and Sm B/B' components of small nuclear ribonucleoproteins confirmed that CRP bound exclusively to these particles. As expected, SAP bound to chromatin and, in addition, binding to the nucleolus was observed for the first time. These interactions demonstrated under relatively physiological conditions, with native pentraxins unseparated from serum and with nuclear constituents in situ, are likely to be of functional importance in vivo.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.