ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology1994
Making first contacts between the spindle and the chromosomes in HeLa cells.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 1994. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed.
- Cellular expression of human centromere protein C demonstrates a cyclic behavior with highest abundance in the G1 phase.Proceedings of the National Academy of Sciences of the United States of America · 1996Article
- Bipolar spindle attachments affect redistributions of ZW10, a Drosophila centromere/kinetochore component required for accurate chromosome segregation.The Journal of cell biology · 1996Article
- Are proteasomes involved in the formation of the kinetochore?Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1996Article
- Immunoelectron microscopic studies on centromere-kinetochore complexes detached from chromosomes.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 1995Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To guarantee an ordered bipartition of the genetic material during mitosis, the chromosomes must be incorporated into the mitotic spindle. In HeLa cells, this process starts early in prophase when the nuclear envelope is still nearly complete, but only a few small holes in the double membranes offer access to the chromosomes for individual microtubules growing out from the poles. Inside the nuclear domain, these microtubules make contact with the kinetochore/centromere complexes which can be found in the vicinity of the hole. These complexes seem to be distributed at random during early prophase until early prometaphase. Therefore, the chromosomes become incorporated in a sequential order. No accumulation of the complexes in the nucleus near the centrosomes can be recognized. The individual microtubules attach tangentially to the kinetochores. This contact can already take place before the kinetochore is fully developed.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.